Detailed information of TA system TA109278

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1864579..1865196
• Replicon: chromosome
• Accession: NZ_CP031505
• Organism: Dickeya fangzhongdai strain LN1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2K8QKH7
• Locus tag: DYD82_RS08385
• Protein ID: WP_071842437.1
• Coordinates: 1864993..1865196 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: DYD82_RS08380
• Protein ID: WP_100849304.1
• Coordinates: 1864579..1864989 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DYD82_RS08355	1860054..1860971	+	918	WP_100849301.1	iron-siderophore ABC transporter substrate-binding protein	-
DYD82_RS08360	1861001..1861990	+	990	WP_167389568.1	iron ABC transporter permease	-
DYD82_RS08365	1862001..1863032	+	1032	WP_039695444.1	iron ABC transporter permease	-
DYD82_RS08370	1863044..1863853	+	810	WP_049854931.1	ABC transporter ATP-binding protein	-
DYD82_RS08375	1863886..1864503	+	618	WP_100849303.1	RraA family protein	-
DYD82_RS08380	1864579..1864989	-	411	WP_100849304.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DYD82_RS08385	1864993..1865196	-	204	WP_071842437.1	type II toxin-antitoxin system HicA family toxin	Toxin
DYD82_RS08390	1865517..1865876	+	360	WP_100849305.1	hypothetical protein	-
DYD82_RS08395	1866181..1867236	-	1056	WP_100849306.1	MBL fold metallo-hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7347.47 Da
• Isoelectric Point: 11.0566

>T109278 WP_071842437.1 NZ_CP031505:c1865196-1864993 [Dickeya fangzhongdai]
MDSRTLIAEIKADGWELVRVNGSHHHFTHPTKPGLVTIPHPKKDLPIGTVKSIRKQAGISSSLTQRG

Nucleotide

• Length: 204 bp

>T109278 NZ_CP031505:c1865196-1864993 [Dickeya fangzhongdai]
ATGGATAGCAGGACGTTGATAGCAGAAATCAAGGCCGATGGATGGGAGCTGGTAAGGGTTAACGGCAGTCATCACCATTT
TACCCACCCAACCAAACCAGGATTAGTGACCATCCCACACCCTAAGAAGGATTTACCGATAGGCACGGTAAAAAGCATCA
GAAAACAAGCGGGGATATCATCCTCACTGACTCAAAGAGGCTGA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14571.59 Da
• Isoelectric Point: 4.3494

>AT109278 WP_100849304.1 NZ_CP031505:c1864989-1864579 [Dickeya fangzhongdai]
MFYPIAIETGDDTHAYGVTVPDLPGCFSAGDTLDEAIANAKEAITGHIELLIEMGQDIPAVSSVGVLAKTPEYTGYTWAV
VDIDVTRLMGGAEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSIR

Nucleotide

• Length: 411 bp

>AT109278 NZ_CP031505:c1864989-1864579 [Dickeya fangzhongdai]
ATGTTTTATCCAATTGCCATTGAAACAGGCGACGATACTCATGCATACGGCGTGACAGTGCCCGATCTGCCGGGCTGTTT
CTCCGCAGGTGATACACTTGATGAGGCTATCGCCAATGCTAAAGAAGCGATCACCGGCCACATAGAGCTGCTGATCGAGA
TGGGCCAGGATATTCCCGCCGTGTCATCCGTAGGTGTGCTGGCGAAAACACCGGAGTACACCGGTTACACCTGGGCTGTT
GTTGATATCGATGTCACTCGGCTGATGGGAGGGGCGGAAAAAATCAACGTCACACTGCCGAAGTCGCTGATTGACCGTAT
AGACCGCTGCGTAGCGAGTAACCCGGAATTTAAGAGCCGCTCAGGATTTCTTGCTCAGGCAGCGTTAGAGCGGATTTCAT
CCATTCGCTAA

Structures

Toxin

• AlphaFold DB: A0A2K8QKH7