Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1961569..1962158 Replicon chromosome
Accession NZ_CP031467
Organism Paraburkholderia caffeinilytica strain CF1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DSC91_RS25045 Protein ID WP_115781327.1
Coordinates 1961569..1961751 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DSC91_RS25050 Protein ID WP_115781328.1
Coordinates 1961748..1962158 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSC91_RS25020 1957282..1957707 - 426 WP_115781322.1 flagellar basal body rod protein FlgC -
DSC91_RS25025 1957907..1958401 - 495 WP_115781323.1 flagellar basal body rod protein FlgB -
DSC91_RS25030 1958629..1960164 + 1536 WP_115781324.1 flagellar basal body P-ring formation protein FlgA -
DSC91_RS25035 1960363..1960719 + 357 WP_115781325.1 flagellar biosynthesis anti-sigma factor FlgM -
DSC91_RS25040 1960814..1961260 + 447 WP_115781326.1 flagellar protein FlgN -
DSC91_RS25045 1961569..1961751 + 183 WP_115781327.1 type II toxin-antitoxin system HicA family toxin Toxin
DSC91_RS25050 1961748..1962158 + 411 WP_115781328.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DSC91_RS25055 1962213..1962947 - 735 WP_115781329.1 RNA polymerase sigma factor FliA -
DSC91_RS25060 1962976..1963845 - 870 WP_115781330.1 MinD/ParA family protein -
DSC91_RS25065 1963838..1965802 - 1965 WP_115781331.1 flagellar biosynthesis protein FlhF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6543.65 Da        Isoelectric Point: 11.3940

>T109263 WP_115781327.1 NZ_CP031467:1961569-1961751 [Paraburkholderia caffeinilytica]
MNSAEVVKVIQADGWRLVRTSGSHHHFRHAVKAGLVTIPHPKKDLPPGTLNSILKQAGLK

Download         Length: 183 bp

>T109263 NZ_CP031467:1961569-1961751 [Paraburkholderia caffeinilytica]
ATGAACAGTGCCGAGGTCGTCAAAGTGATTCAAGCGGATGGTTGGCGGTTGGTCCGCACATCGGGCAGCCACCATCATTT
CCGGCACGCGGTAAAAGCCGGTCTCGTGACCATCCCGCATCCAAAGAAGGACCTTCCGCCCGGCACACTGAACAGCATCT
TGAAACAGGCAGGCCTGAAATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14788.73 Da        Isoelectric Point: 4.6403

>AT109263 WP_115781328.1 NZ_CP031467:1961748-1962158 [Paraburkholderia caffeinilytica]
MKNLIFPIAIEPGDTHQAFGVVVPDIPGCHSAGDSLEEAYASAKEAIEAHLDTLLDEGLPIPERLTLDEHRRNPDYAGFT
WGFVTTRNIPALKKAVRINISLPEALVHDIDAYAQARGMSRSAFLALAAEHEMADA

Download         Length: 411 bp

>AT109263 NZ_CP031467:1961748-1962158 [Paraburkholderia caffeinilytica]
ATGAAGAACCTGATTTTCCCGATCGCGATCGAGCCCGGTGACACACATCAAGCGTTCGGCGTGGTCGTTCCCGACATTCC
GGGTTGCCATTCGGCGGGCGATTCGCTGGAAGAAGCCTATGCGAGCGCAAAGGAAGCAATCGAGGCGCATCTGGATACGC
TGCTCGACGAAGGGTTGCCGATTCCCGAACGGCTGACGCTAGACGAGCATCGGCGCAATCCGGACTATGCGGGTTTCACG
TGGGGGTTCGTCACAACGCGGAATATTCCGGCGTTGAAGAAAGCGGTGCGCATCAATATCTCACTGCCTGAAGCGCTGGT
TCACGATATCGACGCTTATGCCCAGGCGCGCGGCATGTCGCGTTCGGCGTTTCTCGCGCTGGCCGCGGAACATGAGATGG
CAGACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References