Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3351151..3352944 Replicon chromosome
Accession NZ_CP031466
Organism Paraburkholderia caffeinilytica strain CF1

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag DSC91_RS14710 Protein ID WP_115779355.1
Coordinates 3351151..3352041 (+) Length 297 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag DSC91_RS14715 Protein ID WP_115779357.1
Coordinates 3352042..3352944 (+) Length 301 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSC91_RS14680 3346497..3347573 - 1077 WP_115779345.1 porin -
DSC91_RS14685 3348014..3348328 + 315 WP_074289216.1 non-heme iron oxygenase ferredoxin subunit -
DSC91_RS14690 3348330..3348641 + 312 WP_115779347.1 hypothetical protein -
DSC91_RS14695 3348691..3349788 + 1098 WP_115779349.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
DSC91_RS14700 3349781..3350557 + 777 WP_115779351.1 SDR family oxidoreductase -
DSC91_RS14705 3350584..3351111 + 528 WP_115779353.1 cupin domain-containing protein -
DSC91_RS14710 3351151..3352041 + 891 WP_115779355.1 alpha/beta fold hydrolase Toxin
DSC91_RS14715 3352042..3352944 + 903 WP_115779357.1 IclR family transcriptional regulator Antitoxin
DSC91_RS14720 3352941..3353738 + 798 WP_115779359.1 SDR family oxidoreductase -
DSC91_RS14725 3353731..3355389 + 1659 WP_115779369.1 thiamine pyrophosphate-binding protein -
DSC91_RS14730 3355382..3356212 + 831 WP_115779379.1 aspartate dehydrogenase -
DSC91_RS14735 3356253..3357743 + 1491 WP_115779381.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(50-279)

Antitoxin

Transcription regulator IclR, N-terminal

(35-83)


Sequences

Toxin        


Download         Length: 297 a.a.        Molecular weight: 31142.19 Da        Isoelectric Point: 6.1187

>T109260 WP_115779355.1 NZ_CP031466:3351151-3352041 [Paraburkholderia caffeinilytica]
MSALSSATVDQNATFEARLARFPAQQIWLASQRAVSYREADSAESDALPLVLLHGIGSGAASWVQQLEVLGETRRVLAWD
APGYGASTPVAAESPAASDYATVLKEWLDALGIERCVLLGHSLGAIVAGAFAVTNPQRVAGLLLLSPAGGYGAASADVRE
AKRDQRLAMLDELGPQGLAEKRSTNMLSAYASDEARAWVRWNMSRVIPRGYAQATHLLANADLASDLARCRGRISVAVGA
DDTITPPEACARIALAAGTKLQVVPRAGHAGYIEAPAAYSAIIDTFCRASDGQRSQ

Download         Length: 891 bp

>T109260 NZ_CP031466:3351151-3352041 [Paraburkholderia caffeinilytica]
ATGTCTGCACTCTCGTCCGCTACCGTCGATCAGAACGCTACGTTCGAAGCGCGCCTTGCACGCTTTCCCGCGCAGCAGAT
CTGGCTGGCATCGCAACGCGCGGTGAGCTATCGCGAGGCGGATAGCGCCGAAAGCGATGCGCTGCCGCTGGTGTTGTTGC
ACGGTATCGGTTCGGGCGCGGCTTCGTGGGTGCAGCAGCTCGAAGTGCTGGGCGAGACGCGTCGCGTACTGGCATGGGAT
GCGCCGGGGTATGGCGCATCGACACCCGTGGCAGCCGAGTCGCCCGCGGCAAGCGATTACGCAACTGTATTGAAGGAATG
GCTCGACGCGCTCGGCATTGAACGCTGCGTACTGCTGGGTCATTCGCTTGGCGCGATTGTCGCAGGCGCGTTTGCTGTGA
CGAACCCGCAGCGCGTGGCCGGTTTACTGCTGTTGTCACCTGCCGGCGGTTATGGCGCGGCATCCGCTGACGTGCGCGAA
GCCAAACGCGATCAGCGTCTCGCCATGCTCGACGAACTCGGCCCGCAAGGCCTTGCCGAAAAACGCAGCACCAATATGTT
GTCCGCCTACGCGAGCGACGAAGCGCGCGCATGGGTGCGCTGGAACATGTCGCGCGTGATTCCGCGCGGCTATGCGCAAG
CAACGCATCTGCTCGCCAACGCCGATCTCGCCAGCGATCTCGCACGCTGCAGAGGCCGCATCAGCGTCGCGGTCGGCGCA
GACGACACCATTACCCCTCCCGAAGCCTGCGCGCGGATCGCATTGGCCGCGGGCACCAAACTGCAGGTCGTGCCGCGCGC
CGGGCACGCCGGCTATATCGAAGCACCCGCCGCGTACAGCGCGATTATCGACACGTTCTGCCGCGCGAGCGACGGACAAC
GGAGCCAATGA

Antitoxin


Download         Length: 301 a.a.        Molecular weight: 33297.74 Da        Isoelectric Point: 6.3678

>AT109260 WP_115779357.1 NZ_CP031466:3352042-3352944 [Paraburkholderia caffeinilytica]
MTSDTHDIVSAERDADDDRNDADTSSDTSYRVPGLERGLKILTEFSPREPVLGAPELSKRLKIPRTTVFRLLQTLESLGF
LERADKDRNYRLGVAVLRLGFEYLSSLELTDLGLPIIEALRDDTGLTSHIVIRDGRDVVFVAKAQSHTPIFSSVKVNVGT
RLPAYATTHGQVLMGDMTLDDLKKLYPEPELERFTKQTPATVDDLYERIRDDAKRGFAISESSFERGISVVSAPVRNDTG
RIVAVITTTIPRHEIDASLLDSGLIDKVRRAADELSQRLNYRPKGGPNAGAKYFKALGLK

Download         Length: 903 bp

>AT109260 NZ_CP031466:3352042-3352944 [Paraburkholderia caffeinilytica]
ATGACGTCCGACACGCATGACATCGTTAGCGCCGAGCGCGACGCGGACGACGACCGCAACGACGCAGACACGAGCAGCGA
TACCAGCTATCGCGTGCCGGGTCTGGAGCGCGGTCTGAAGATTCTGACGGAGTTCTCGCCGCGCGAGCCGGTTCTCGGCG
CACCGGAATTATCGAAGCGCCTGAAGATTCCCCGCACGACGGTGTTCCGTCTGCTGCAAACGCTCGAATCGCTCGGCTTT
CTCGAGCGTGCCGATAAAGACCGCAACTATCGCCTCGGCGTCGCGGTACTGCGACTCGGTTTCGAATATCTGAGCTCGCT
CGAATTGACCGACCTCGGTTTGCCGATCATCGAAGCGCTGCGCGACGATACCGGCTTGACGAGCCACATCGTGATACGCG
ACGGACGCGATGTGGTGTTCGTTGCCAAGGCGCAAAGCCACACGCCGATTTTCAGTTCGGTGAAGGTGAATGTCGGCACC
CGTCTGCCTGCCTACGCGACGACGCACGGCCAGGTGTTGATGGGCGACATGACGCTCGACGACTTGAAGAAGCTCTATCC
CGAGCCGGAACTCGAACGCTTCACGAAACAAACGCCCGCGACGGTCGACGATCTGTACGAACGGATTCGCGACGACGCCA
AGCGTGGCTTCGCGATCAGCGAGTCGTCGTTCGAACGCGGCATCTCGGTGGTGAGCGCGCCGGTGCGTAACGACACGGGC
CGCATCGTCGCCGTGATCACCACGACGATTCCGCGCCACGAGATCGACGCGTCACTGCTCGACAGCGGCCTGATCGACAA
GGTCCGCCGCGCGGCTGACGAACTGTCGCAGCGGCTCAACTATCGGCCAAAGGGTGGCCCGAACGCGGGCGCGAAATACT
TTAAGGCACTGGGGCTCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References