Detailed information of TA system TA109242

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2862736..2863292
• Replicon: chromosome
• Accession: NZ_CP031461
• Organism: Xanthomonas oryzae pv. oryzae strain OS198

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BRN32_RS14345
• Protein ID: WP_229001948.1
• Coordinates: 2862736..2862987 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: BRN32_RS14350
• Protein ID: WP_011408759.1
• Coordinates: 2863014..2863292 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BRN32_RS14295 (BRN32_14295)	2858506..2859597	+	1092	WP_041182166.1	ribonuclease D	-
BRN32_RS14300 (BRN32_14300)	2859673..2860010	-	338	Protein_2599	ATP-dependent DNA ligase	-
BRN32_RS25385 (BRN32_14310)	2860292..2860468	-	177	Protein_2600	DUF3606 domain-containing protein	-
BRN32_RS14315 (BRN32_14315)	2860690..2861091	+	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
BRN32_RS25390	2861522..2861650	-	129	WP_012444694.1	hypothetical protein	-
BRN32_RS25395 (BRN32_14330)	2861619..2861738	-	120	Protein_2603	IS3 family transposase	-
BRN32_RS14335 (BRN32_14335)	2861955..2862209	-	255	WP_223293127.1	hypothetical protein	-
BRN32_RS25400	2862278..2862412	-	135	WP_011051575.1	hypothetical protein	-
BRN32_RS14340 (BRN32_14340)	2862405..2862659	-	255	WP_198912806.1	hypothetical protein	-
BRN32_RS14345 (BRN32_14345)	2862736..2862987	-	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BRN32_RS14350 (BRN32_14350)	2863014..2863292	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
BRN32_RS14355 (BRN32_14355)	2863488..2863832	-	345	WP_199285675.1	hypothetical protein	-
BRN32_RS14365 (BRN32_14365)	2864738..2865922	-	1185	WP_151420524.1	IS256-like element IS1113 family transposase	-
BRN32_RS14375 (BRN32_14375)	2866494..2867459	+	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
BRN32_RS14380 (BRN32_14380)	2867609..2868166	+	558	WP_011259349.1	DNA-3-methyladenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T109242 WP_229001948.1 NZ_CP031461:c2862987-2862736 [Xanthomonas oryzae pv. oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T109242 NZ_CP031461:c2862987-2862736 [Xanthomonas oryzae pv. oryzae]
ATGCTACGGCTGCGTGAATTCCTGAGGCCGAAGAATCCCGATGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGT
CCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAGAAGATCTGTCTGAACAGTATCGGGAGTGGCTTATCGATT
TTGGGGATAGCGGCTATGTGGCTCGGTACCGCTTCGATGGGGATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAA
GCGGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT109242 WP_011408759.1 NZ_CP031461:c2863292-2863014 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT109242 NZ_CP031461:c2863292-2863014 [Xanthomonas oryzae pv. oryzae]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCAGAGTCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCATGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2