Detailed information of TA system TA109238

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2899178..2899734
• Replicon: chromosome
• Accession: NZ_CP031460
• Organism: Xanthomonas oryzae pv. oryzae strain JP01

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BRM88_RS14495
• Protein ID: WP_027703932.1
• Coordinates: 2899178..2899468 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: BRM88_RS14500
• Protein ID: WP_011408759.1
• Coordinates: 2899456..2899734 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BRM88_RS14445	2894948..2896039	+	1092	WP_011408756.1	ribonuclease D	-
BRM88_RS14450	2896136..2896452	-	317	Protein_2604	ATP-dependent DNA ligase	-
BRM88_RS24860	2896512..2896718	-	207	Protein_2605	hypothetical protein	-
BRM88_RS25135	2896734..2896910	-	177	Protein_2606	DUF3606 domain-containing protein	-
BRM88_RS14465	2897132..2897533	+	402	WP_011259345.1	H-NS histone family protein	-
BRM88_RS14485	2898397..2898576	-	180	WP_015463309.1	hypothetical protein	-
BRM88_RS14490	2898847..2899101	-	255	WP_198912806.1	hypothetical protein	-
BRM88_RS14495	2899178..2899468	-	291	WP_027703932.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BRM88_RS14500	2899456..2899734	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
BRM88_RS25140	2899815..2900018	-	204	WP_199285669.1	hypothetical protein	-
BRM88_RS25145	2899930..2900274	-	345	WP_199285675.1	hypothetical protein	-
BRM88_RS14510	2900219..2900419	-	201	WP_027703931.1	ribbon-helix-helix protein, CopG family	-
BRM88_RS14515	2901180..2902364	-	1185	WP_011408760.1	IS256 family transposase	-
BRM88_RS14525	2902945..2903910	+	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
BRM88_RS14530	2904012..2904617	+	606	Protein_2617	DNA-3-methyladenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10915.48 Da
• Isoelectric Point: 9.5554

>T109238 WP_027703932.1 NZ_CP031460:c2899468-2899178 [Xanthomonas oryzae pv. oryzae]
MPQVIFAPAAIGDMLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T109238 NZ_CP031460:c2899468-2899178 [Xanthomonas oryzae pv. oryzae]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCTACGGCTGCGTGAATTCCTGAGGCCGAAGAATCCCGA
TGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAG
AAGATCTGTCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGCGGCTATGTGGCTCGGTACCGCTTCGATGGG
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCGGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT109238 WP_011408759.1 NZ_CP031460:c2899734-2899456 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT109238 NZ_CP031460:c2899734-2899456 [Xanthomonas oryzae pv. oryzae]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCAGAGTCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCATGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCTAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2