Detailed information of TA system TA109234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2847519..2848075
• Replicon: chromosome
• Accession: NZ_CP031459
• Organism: Xanthomonas oryzae pv. oryzae strain JL33

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BRM84_RS14165
• Protein ID: WP_027703932.1
• Coordinates: 2847519..2847809 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: BRM84_RS14170
• Protein ID: WP_011408759.1
• Coordinates: 2847797..2848075 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BRM84_RS14115	2843289..2844380	+	1092	WP_041182166.1	ribonuclease D	-
BRM84_RS14120	2844456..2844793	-	338	Protein_2542	ATP-dependent DNA ligase	-
BRM84_RS24520	2844853..2845059	-	207	Protein_2543	hypothetical protein	-
BRM84_RS24790	2845075..2845251	-	177	Protein_2544	DUF3606 domain-containing protein	-
BRM84_RS14135	2845473..2845874	+	402	WP_011259345.1	H-NS histone family protein	-
BRM84_RS14155	2846738..2846917	-	180	WP_015463309.1	hypothetical protein	-
BRM84_RS14160	2847188..2847442	-	255	WP_198912806.1	hypothetical protein	-
BRM84_RS14165	2847519..2847809	-	291	WP_027703932.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BRM84_RS14170	2847797..2848075	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
BRM84_RS24795	2848156..2848359	-	204	WP_199285669.1	hypothetical protein	-
BRM84_RS24800	2848271..2848615	-	345	WP_199285675.1	hypothetical protein	-
BRM84_RS14180	2848560..2848760	-	201	WP_027703931.1	ribbon-helix-helix protein, CopG family	-
BRM84_RS14185	2849521..2850705	-	1185	WP_011408760.1	IS256 family transposase	-
BRM84_RS14195	2851286..2852251	+	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
BRM84_RS14200	2852353..2852958	+	606	Protein_2555	DNA-3-methyladenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10915.48 Da
• Isoelectric Point: 9.5554

>T109234 WP_027703932.1 NZ_CP031459:c2847809-2847519 [Xanthomonas oryzae pv. oryzae]
MPQVIFAPAAIGDMLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T109234 NZ_CP031459:c2847809-2847519 [Xanthomonas oryzae pv. oryzae]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCTACGGCTGCGTGAATTCCTGAGGCCGAAGAATCCCGA
TGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAG
AAGATCTGTCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGCGGCTATGTGGCTCGGTACCGCTTCGATGGG
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCGGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT109234 WP_011408759.1 NZ_CP031459:c2848075-2847797 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT109234 NZ_CP031459:c2848075-2847797 [Xanthomonas oryzae pv. oryzae]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCAGAGTCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCATGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCTAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2