Detailed information of TA system TA109226

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1781635..1782191
• Replicon: chromosome
• Accession: NZ_CP031457
• Organism: Xanthomonas oryzae pv. oryzae strain JL25

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BRM77_RS09005
• Protein ID: WP_027703932.1
• Coordinates: 1781635..1781925 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: BRM77_RS09010
• Protein ID: WP_011408759.1
• Coordinates: 1781913..1782191 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BRM77_RS08955	1777405..1778496	+	1092	WP_041182166.1	ribonuclease D	-
BRM77_RS08960	1778572..1778909	-	338	Protein_1607	ATP-dependent DNA ligase	-
BRM77_RS24425	1778969..1779175	-	207	Protein_1608	hypothetical protein	-
BRM77_RS24810	1779191..1779367	-	177	Protein_1609	DUF3606 domain-containing protein	-
BRM77_RS08975	1779589..1779990	+	402	WP_011259345.1	H-NS histone family protein	-
BRM77_RS08995	1780854..1781033	-	180	WP_015463309.1	hypothetical protein	-
BRM77_RS24815	1781177..1781374	-	198	WP_004541336.1	hypothetical protein	-
BRM77_RS09005	1781635..1781925	-	291	WP_027703932.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BRM77_RS09010	1781913..1782191	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
BRM77_RS24820	1782272..1782475	-	204	WP_199285669.1	hypothetical protein	-
BRM77_RS24825	1782387..1782731	-	345	WP_199285675.1	hypothetical protein	-
BRM77_RS09020	1782676..1782876	-	201	WP_027703931.1	ribbon-helix-helix protein, CopG family	-
BRM77_RS09025	1783637..1784821	-	1185	WP_011408760.1	IS256 family transposase	-
BRM77_RS09035	1785402..1786367	+	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
BRM77_RS09040	1786469..1787074	+	606	Protein_1620	DNA-3-methyladenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10915.48 Da
• Isoelectric Point: 9.5554

>T109226 WP_027703932.1 NZ_CP031457:c1781925-1781635 [Xanthomonas oryzae pv. oryzae]
MPQVIFAPAAIGDMLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T109226 NZ_CP031457:c1781925-1781635 [Xanthomonas oryzae pv. oryzae]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCTACGGCTGCGTGAATTCCTGAGGCCGAAGAATCCCGA
TGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAG
AAGATCTGTCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGCGGCTATGTGGCTCGGTACCGCTTCGATGGG
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCGGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT109226 WP_011408759.1 NZ_CP031457:c1782191-1781913 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT109226 NZ_CP031457:c1782191-1781913 [Xanthomonas oryzae pv. oryzae]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCAGAGTCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCATGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCTAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2