Detailed information of TA system TA109220

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 6115413..6115938
• Replicon: chromosome
• Accession: NZ_CP031455
• Organism: Streptomyces olivoreticuli subsp. olivoreticuli strain ATCC 31159

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DXZ73_RS27245
• Protein ID: WP_116213678.1
• Coordinates: 6115413..6115676 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DXZ73_RS27250
• Protein ID: WP_116213679.1
• Coordinates: 6115669..6115938 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXZ73_RS27230	6111020..6111301	+	282	WP_116213676.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
DXZ73_RS27235	6111298..6111552	+	255	WP_116213677.1	Txe/YoeB family addiction module toxin	-
DXZ73_RS27240	6111658..6115176	-	3519	WP_162890351.1	ATP-binding protein	-
DXZ73_RS27245	6115413..6115676	-	264	WP_116213678.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DXZ73_RS27250	6115669..6115938	-	270	WP_116213679.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DXZ73_RS27255	6116024..6116533	-	510	WP_116215888.1	SgcJ/EcaC family oxidoreductase	-
DXZ73_RS27260	6116709..6117284	-	576	WP_116213680.1	Uma2 family endonuclease	-
DXZ73_RS27265	6117353..6118297	-	945	WP_116213681.1	alpha/beta hydrolase	-
DXZ73_RS27270	6118659..6119411	+	753	WP_116215889.1	GntR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (16-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-60)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10112.56 Da
• Isoelectric Point: 9.5570

>T109220 WP_116213678.1 NZ_CP031455:c6115676-6115413 [Streptomyces olivoreticuli subsp. olivoreticuli]
VSNYRTVFRPEAHAELRKIPRDMALRILAKLTELESDPFGFNTTALVSQPERRRLRVGDYRVVYTIDNGELVVWVVHVGH
RSTVYET

Nucleotide

• Length: 264 bp

>T109220 NZ_CP031455:c6115676-6115413 [Streptomyces olivoreticuli subsp. olivoreticuli]
GTGAGTAACTACCGCACCGTCTTTCGTCCCGAGGCCCATGCCGAGCTTCGAAAGATCCCACGGGACATGGCCCTGCGCAT
CCTGGCCAAGCTGACAGAGCTGGAGAGTGACCCCTTCGGCTTCAACACCACCGCACTCGTCTCCCAGCCGGAGCGCCGCC
GCCTACGAGTCGGCGACTACCGGGTCGTCTACACCATCGACAACGGCGAACTGGTCGTGTGGGTCGTTCACGTCGGACAT
CGCTCCACCGTTTACGAGACCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10253.71 Da
• Isoelectric Point: 4.9372

>AT109220 WP_116213679.1 NZ_CP031455:c6115938-6115669 [Streptomyces olivoreticuli subsp. olivoreticuli]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIDVLRKYQKWEEQEINRIIDERMANRSAGIPIEDV
MKETLARSE

Nucleotide

• Length: 270 bp

>AT109220 NZ_CP031455:c6115938-6115669 [Streptomyces olivoreticuli subsp. olivoreticuli]
ATGACGCAGCCGCTGCCCATAGAGTCCATCCGTGACGTCCGCGCGCACTTGGCCGAAGTCGTCGAACGGGCCGACCGTGA
CGACGTGCCCACCGTGATCACACGACGGGGCAAGGAGGTCGCCGCCGTCGTCTCGATCGACGTCCTGCGCAAGTACCAGA
AGTGGGAAGAGCAGGAGATCAACCGGATCATCGACGAGCGCATGGCGAACCGTTCGGCTGGCATCCCGATCGAGGACGTC
ATGAAGGAGACGCTGGCGCGCAGTGAGTAA