Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3311652..3313495 Replicon chromosome
Accession NZ_CP031454
Organism Burkholderia gladioli strain Lv-StA

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag DX980_RS34720 Protein ID WP_105850547.1
Coordinates 3311652..3312617 (+) Length 322 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag DX980_RS34725 Protein ID WP_236669412.1
Coordinates 3312614..3313495 (+) Length 294 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DX980_RS34690 (DX980_34375) 3306960..3308039 - 1080 WP_160294861.1 porin -
DX980_RS34695 (DX980_34380) 3308454..3308771 + 318 WP_013689902.1 non-heme iron oxygenase ferredoxin subunit -
DX980_RS34700 (DX980_34385) 3308774..3309085 + 312 WP_025097963.1 hypothetical protein -
DX980_RS34705 (DX980_34390) 3309127..3310236 + 1110 WP_025097964.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
DX980_RS34710 (DX980_34395) 3310229..3310999 + 771 WP_105850498.1 SDR family oxidoreductase -
DX980_RS34715 (DX980_34400) 3311098..3311625 + 528 WP_036038832.1 cupin domain-containing protein -
DX980_RS34720 (DX980_34405) 3311652..3312617 + 966 WP_105850547.1 alpha/beta fold hydrolase Toxin
DX980_RS34725 (DX980_34410) 3312614..3313495 + 882 WP_236669412.1 IclR family transcriptional regulator Antitoxin
DX980_RS34730 (DX980_34415) 3313492..3314289 + 798 WP_096750801.1 SDR family oxidoreductase -
DX980_RS34735 (DX980_34420) 3314282..3315955 + 1674 WP_160294862.1 thiamine pyrophosphate-binding protein -
DX980_RS34740 (DX980_34425) 3315948..3316781 + 834 WP_160294863.1 aspartate dehydrogenase -
DX980_RS34745 (DX980_34430) 3316858..3318348 + 1491 WP_046574265.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(66-305)

Antitoxin

Transcription regulator IclR, C-terminal

(151-274)


Sequences

Toxin        


Download         Length: 322 a.a.        Molecular weight: 32925.41 Da        Isoelectric Point: 7.0329

>T109216 WP_105850547.1 NZ_CP031454:3311652-3312617 [Burkholderia gladioli]
MSEIDPRGAEAEAGPDAALAARLWQFPARRIAIREAGLIGWRESGPAQGAGDSTARAAAGERALPVVLLHGIGSGAASWL
AQLDTLGASRRVLAWDAPGYGESTPVAPASPLAADYAASLAGWLDALAIERCVLVGHSLGAIVAGAFARRHAGRLAGLLL
VSPAAGYGAAPAATRDERRDARLAMLAALGPAGLAEQRSANMLSAHAGEAARAWVRRVMAQVKPAGYTQATHLLANADLA
ADLAAWRAMTDAAGAARVEVMVGAEDGITPPNACERIAAAAGVALRIVPRAGHAGYVEAPERYSELIGAFCARCDESWRQ
A

Download         Length: 966 bp

>T109216 NZ_CP031454:3311652-3312617 [Burkholderia gladioli]
ATGAGCGAAATCGATCCGCGCGGGGCCGAGGCAGAGGCTGGGCCCGACGCGGCCCTGGCCGCCCGACTCTGGCAGTTTCC
GGCGCGGCGCATCGCCATTCGCGAAGCCGGGCTGATCGGCTGGCGCGAATCGGGTCCAGCGCAGGGGGCCGGCGATTCGA
CGGCACGCGCGGCCGCTGGCGAGCGGGCATTGCCGGTGGTGCTGCTGCACGGCATCGGCTCGGGCGCGGCCTCGTGGCTG
GCCCAGCTCGACACGCTCGGCGCGTCGCGTCGCGTGCTGGCCTGGGACGCGCCCGGTTATGGCGAATCGACGCCGGTCGC
GCCGGCCTCGCCGCTGGCGGCCGATTACGCGGCGTCGCTGGCCGGCTGGCTCGACGCGCTCGCCATCGAGCGCTGCGTGC
TGGTGGGGCACTCGCTCGGCGCGATCGTGGCCGGCGCCTTCGCGCGCCGGCATGCCGGGCGGCTGGCCGGCTTGCTGCTG
GTTTCGCCGGCCGCCGGCTACGGCGCGGCACCGGCCGCCACGCGCGACGAACGGCGCGATGCGCGGCTCGCGATGCTGGC
CGCGCTCGGGCCCGCGGGCCTGGCCGAACAACGCAGCGCCAACATGCTGTCGGCGCATGCCGGCGAGGCCGCCCGCGCCT
GGGTGCGCCGCGTGATGGCGCAGGTGAAGCCGGCCGGCTACACGCAGGCCACCCACCTGCTCGCGAACGCCGACCTGGCC
GCCGATCTCGCCGCCTGGCGGGCGATGACCGACGCCGCCGGTGCCGCGCGCGTGGAGGTGATGGTGGGCGCCGAGGACGG
CATCACGCCGCCGAACGCCTGCGAACGGATCGCGGCGGCGGCCGGCGTGGCGCTGCGTATCGTGCCGCGCGCCGGCCATG
CCGGCTACGTGGAGGCACCCGAGCGCTACTCAGAGCTGATCGGCGCGTTCTGCGCGCGCTGCGACGAATCATGGAGACAG
GCATGA

Antitoxin


Download         Length: 294 a.a.        Molecular weight: 31815.26 Da        Isoelectric Point: 6.5132

>AT109216 WP_236669412.1 NZ_CP031454:3312614-3313495 [Burkholderia gladioli]
MNPTQLALRSEPADSGAPEADAANGAYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLER
ADKDRNYRLGVAVLRLGFEYLSSLELTDLGLPVIEGLREATGFTTHIVIRDGRDVVFVAKAQSAAPAFSSIRVNVGTRLP
AHATTHGHVLMGDLSEAELRALYPERQLERATRATPDSLEALLVLVREDAARGYGISNSSFERGISVVTAPVRNDTQRIV
AAVTVTVPKPEIDAALIADGLVEKVVRAANELSRRLNYRSDDENSYLKALGLR

Download         Length: 882 bp

>AT109216 NZ_CP031454:3312614-3313495 [Burkholderia gladioli]
ATGAACCCGACCCAACTCGCCCTGCGAAGCGAGCCGGCCGACAGCGGCGCGCCCGAGGCGGATGCCGCGAACGGCGCCTA
CGTGGTACCTGGACTCGAACGCGGGCTGCGGATCCTCGCGGAATTCTCGCCGCGCGAGCCGGTGCTGGGCGCGCCGGAAT
TGTCGAAGCGGCTCGGCATTCCGCGCACCACGGTGTTCCGGCTGCTGCAGACGCTCGAATCGCTGGGCTTCCTGGAGCGC
GCCGACAAGGACCGCAATTACCGGCTCGGCGTGGCGGTGCTGCGCCTGGGCTTCGAATACTTGAGCTCGCTGGAGCTGAC
CGACCTGGGCTTGCCAGTGATCGAGGGCCTGCGCGAGGCGACCGGCTTCACCACCCATATCGTGATCCGCGACGGCCGCG
ACGTGGTGTTCGTCGCCAAGGCGCAGAGCGCGGCGCCGGCCTTCAGCTCGATTCGCGTCAACGTCGGCACGCGGCTGCCC
GCGCATGCCACTACCCACGGCCACGTGCTGATGGGCGACCTGAGCGAGGCCGAGCTGCGCGCACTGTACCCCGAGCGCCA
GCTCGAACGGGCCACGCGTGCCACGCCCGACAGCCTGGAGGCGCTGCTCGTGCTGGTCCGCGAGGATGCCGCGCGCGGCT
ACGGCATCAGCAACTCCTCGTTCGAGCGCGGCATCTCGGTGGTCACCGCGCCGGTGCGCAACGACACGCAGCGCATCGTG
GCGGCCGTCACGGTGACGGTGCCGAAACCCGAGATCGACGCGGCGCTGATCGCCGACGGCCTGGTCGAGAAGGTCGTGAG
GGCGGCCAATGAACTGTCGCGGCGGCTCAATTACCGCTCCGATGATGAGAACTCCTATCTGAAGGCATTGGGATTGCGAT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References