Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 2109975..2110495 Replicon chromosome
Accession NZ_CP031454
Organism Burkholderia gladioli strain Lv-StA

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag DX980_RS29935 Protein ID WP_084152421.1
Coordinates 2110271..2110495 (-) Length 75 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DX980_RS29930 Protein ID WP_036032828.1
Coordinates 2109975..2110274 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DX980_RS29905 (DX980_29560) 2105319..2105774 - 456 WP_013689018.1 CesT family type III secretion system chaperone -
DX980_RS29910 (DX980_29565) 2105895..2106179 - 285 WP_172535078.1 hypothetical protein -
DX980_RS29915 (DX980_29570) 2106351..2106596 - 246 WP_046576040.1 hypothetical protein -
DX980_RS29920 (DX980_29575) 2106626..2108032 - 1407 WP_105827196.1 type III secretion protein -
DX980_RS29925 (DX980_29580) 2108680..2109870 + 1191 WP_160294540.1 MFS transporter -
DX980_RS29930 (DX980_29585) 2109975..2110274 - 300 WP_036032828.1 putative addiction module antidote protein Antitoxin
DX980_RS29935 (DX980_29590) 2110271..2110495 - 225 WP_084152421.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DX980_RS29940 (DX980_29595) 2110783..2112336 + 1554 WP_160294541.1 hypothetical protein -
DX980_RS29945 (DX980_29600) 2112371..2112826 + 456 WP_160294542.1 NUDIX domain-containing protein -
DX980_RS29950 (DX980_29605) 2112883..2114307 - 1425 WP_160294543.1 class I SAM-dependent methyltransferase -
DX980_RS29955 (DX980_29610) 2114754..2115245 + 492 WP_025097476.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(18-69)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-92)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8134.38 Da        Isoelectric Point: 10.1935

>T109214 WP_084152421.1 NZ_CP031454:c2110495-2110271 [Burkholderia gladioli]
MAFFGYRIPDNRHACARGNGVSELRIDHGPGYRVYYMKRGRVVVILLCGGNKDSQGHDIAVAKAIAAQWKGSTI

Download         Length: 225 bp

>T109214 NZ_CP031454:c2110495-2110271 [Burkholderia gladioli]
ATGGCTTTTTTCGGATATCGCATCCCGGACAATCGACACGCCTGCGCCCGTGGCAACGGTGTCTCGGAACTGCGAATCGA
CCATGGCCCTGGATATCGGGTCTACTACATGAAGCGAGGCCGCGTCGTGGTCATATTGCTATGCGGCGGCAATAAGGATA
GTCAAGGTCATGACATTGCCGTCGCCAAGGCAATCGCTGCGCAATGGAAGGGGTCCACGATATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10596.95 Da        Isoelectric Point: 4.7420

>AT109214 WP_036032828.1 NZ_CP031454:c2110274-2109975 [Burkholderia gladioli]
MKAVKFSRYDTVDYLQTEEEIAAYLDAAVEDGDPALIAAALGDIARARNISQLARDTGMSREGIYRALSGDGNPSFATVM
KIANALGLRISFRPATSSP

Download         Length: 300 bp

>AT109214 NZ_CP031454:c2110274-2109975 [Burkholderia gladioli]
ATGAAAGCCGTGAAGTTCAGTCGATACGATACCGTCGACTATCTGCAGACCGAGGAGGAGATTGCCGCCTACCTCGACGC
TGCGGTCGAAGACGGCGATCCGGCCTTGATCGCCGCAGCCCTTGGTGACATCGCGCGTGCGCGAAATATCAGCCAACTCG
CGCGCGATACCGGCATGAGTCGCGAAGGCATTTATCGGGCCCTGTCGGGTGACGGCAATCCGAGTTTTGCTACCGTGATG
AAAATTGCGAATGCGCTTGGGCTACGGATATCCTTTCGACCCGCGACATCGAGCCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References