Detailed information of TA system TA109213

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 496278..496920
• Replicon: chromosome
• Accession: NZ_CP031454
• Organism: Burkholderia gladioli strain Lv-StA

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: F2LQ48
• Locus tag: DX980_RS22995
• Protein ID: WP_013690721.1
• Coordinates: 496278..496700 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DX980_RS23000
• Protein ID: WP_105827555.1
• Coordinates: 496687..496920 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DX980_RS22975 (DX980_22805)	492078..493451	+	1374	WP_160294102.1	L-fucose:H+ symporter permease	-
DX980_RS22980 (DX980_22810)	493454..494536	+	1083	WP_160294103.1	aldose 1-epimerase family protein	-
DX980_RS22985 (DX980_22815)	494556..495326	-	771	WP_025101959.1	DNA-binding transcriptional repressor DeoR	-
DX980_RS22990 (DX980_22820)	495476..496156	+	681	WP_160294104.1	deoxyribose-phosphate aldolase	-
DX980_RS22995 (DX980_22825)	496278..496700	-	423	WP_013690721.1	type II toxin-antitoxin system VapC family toxin	Toxin
DX980_RS23000 (DX980_22830)	496687..496920	-	234	WP_105827555.1	DNA-binding protein	Antitoxin
DX980_RS23005	497013..497645	-	633	WP_160294105.1	hypothetical protein	-
DX980_RS23010 (DX980_22835)	497767..498882	+	1116	WP_236669348.1	flavodoxin family protein	-
DX980_RS23015 (DX980_22840)	499101..500237	+	1137	WP_013690743.1	glutathione-independent formaldehyde dehydrogenase	-
DX980_RS23020 (DX980_22845)	500316..500561	-	246	WP_201446961.1	hypothetical protein	-
DX980_RS23025 (DX980_22850)	500554..500781	-	228	WP_105853279.1	hypothetical protein	-
DX980_RS23030 (DX980_22855)	501003..501320	-	318	WP_124083530.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15649.91 Da
• Isoelectric Point: 8.5438

>T109213 WP_013690721.1 NZ_CP031454:c496700-496278 [Burkholderia gladioli]
MYLIDTNVVSEVRKRDRADKGVMAFFRQAARDDAGLYLSVVTVGELRRGVEIIRHRGDESQATRLANWLDGVLREFAANI
LVVDKEIGQMWGYLRVPRSEHSLDKVIAATALIHDLTVVTRNVDDFAGTGARVLNPFKGP

Nucleotide

• Length: 423 bp

>T109213 NZ_CP031454:c496700-496278 [Burkholderia gladioli]
ATGTATTTGATTGACACCAATGTGGTCAGCGAAGTCCGGAAACGGGATCGTGCGGACAAGGGCGTGATGGCCTTCTTTCG
CCAGGCGGCCCGCGACGATGCCGGCCTGTACCTGTCGGTGGTGACGGTGGGCGAACTGCGTCGAGGTGTGGAAATCATCC
GTCACCGTGGCGACGAATCCCAGGCAACGCGTCTCGCGAACTGGCTCGATGGCGTGCTCCGGGAGTTTGCCGCGAACATT
CTCGTGGTGGACAAGGAGATCGGGCAGATGTGGGGCTACCTGCGTGTACCTCGCTCGGAACATTCGCTGGATAAGGTGAT
CGCCGCCACGGCCTTGATTCACGATCTGACCGTGGTGACGCGCAACGTGGATGATTTCGCCGGAACCGGTGCCCGTGTGC
TGAACCCGTTCAAGGGCCCATAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8512.67 Da
• Isoelectric Point: 5.5741

>AT109213 WP_105827555.1 NZ_CP031454:c496920-496687 [Burkholderia gladioli]
MANLLVRNVDEMLVQILRERAAAHGHSAEAEHRAILARALREPQRKTFAQVLMGMPNVGSDVDFARVDDGEAANVFD

Nucleotide

• Length: 234 bp

>AT109213 NZ_CP031454:c496920-496687 [Burkholderia gladioli]
ATGGCGAATCTTCTGGTGAGAAACGTGGACGAAATGCTTGTTCAAATCTTGCGCGAGCGGGCTGCCGCTCACGGGCACAG
CGCGGAAGCCGAGCATCGTGCAATCCTGGCAAGGGCGCTGCGCGAGCCGCAGCGCAAGACATTCGCGCAAGTGCTGATGG
GCATGCCGAACGTCGGTAGCGATGTCGATTTTGCGCGCGTGGACGATGGCGAGGCGGCGAATGTATTTGATTGA

Structures

Toxin

• AlphaFold DB: A0A833Q1H0