Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1247348..1248624 Replicon chromosome
Accession NZ_CP031452
Organism Burkholderia gladioli strain Lv-StA

Toxin (Protein)


Gene name vapC Uniprot ID A0A833Q958
Locus tag DX980_RS06355 Protein ID WP_046582256.1
Coordinates 1247348..1247932 (-) Length 195 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DX980_RS06360 Protein ID WP_103690443.1
Coordinates 1248034..1248624 (-) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DX980_RS06325 (DX980_06255) 1242657..1243214 + 558 WP_236669269.1 DUF302 domain-containing protein -
DX980_RS06330 (DX980_06260) 1243339..1244301 - 963 WP_046582898.1 AraC family transcriptional regulator -
DX980_RS06335 1244496..1245314 - 819 WP_186078337.1 transglycosylase SLT domain-containing protein -
DX980_RS06340 (DX980_06270) 1245719..1246456 - 738 WP_046582311.1 hypothetical protein -
DX980_RS06345 (DX980_06275) 1246644..1246853 - 210 WP_155420033.1 hypothetical protein -
DX980_RS06355 (DX980_06285) 1247348..1247932 - 585 WP_046582256.1 HD domain-containing protein Toxin
DX980_RS06360 (DX980_06290) 1248034..1248624 - 591 WP_103690443.1 helix-turn-helix transcriptional regulator Antitoxin
DX980_RS06365 (DX980_06295) 1248776..1249039 - 264 WP_013698802.1 PAAR domain-containing protein -
DX980_RS06370 (DX980_06300) 1249106..1249540 - 435 WP_160292973.1 hypothetical protein -
DX980_RS06375 (DX980_06305) 1249584..1251599 - 2016 WP_160292974.1 sodium:solute symporter family protein -
DX980_RS06380 (DX980_06310) 1251593..1252030 - 438 WP_080742279.1 DUF4212 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(8-183)

Antitoxin

Cro/C1-type helix-turn-helix domain

(27-73)


Sequences

Toxin        


Download         Length: 195 a.a.        Molecular weight: 21541.29 Da        Isoelectric Point: 5.0097

>T109211 WP_046582256.1 NZ_CP031452:c1247932-1247348 [Burkholderia gladioli]
MDDALIDARLDFLRGCERLKDVLRSGHTSGGRRESTAEHSWRLALMAMVLMDQLGEVDPGRVLELCLVHDLGEALGGDVP
APEQAPGSDKDAVERRDLLRLGDALDAPMRERIVALWDEYARAATPEARAVKALDKIETILQHTQGENPPDFDYAFNLSY
GQAHTRKVPALQRFRERLDEATRERMARAGGPSG

Download         Length: 585 bp

>T109211 NZ_CP031452:c1247932-1247348 [Burkholderia gladioli]
ATGGACGACGCGTTGATCGACGCACGACTGGATTTCCTGCGCGGCTGCGAGCGCCTGAAGGATGTGCTGCGCAGCGGCCA
TACCTCGGGCGGGCGACGCGAGAGCACGGCCGAGCACAGCTGGCGGCTCGCGCTGATGGCGATGGTGCTGATGGATCAAT
TGGGCGAGGTCGACCCCGGCAGGGTGCTCGAGCTCTGCCTGGTGCATGACCTGGGCGAAGCGCTGGGCGGCGACGTGCCG
GCGCCCGAGCAGGCCCCGGGCAGCGACAAGGATGCCGTCGAGCGACGCGACCTGCTGCGCCTCGGCGACGCGCTCGATGC
GCCGATGCGCGAGAGGATCGTCGCGTTGTGGGACGAGTATGCGCGGGCGGCCACGCCGGAAGCACGCGCGGTGAAGGCGC
TCGACAAGATCGAGACGATCCTGCAGCACACGCAGGGCGAGAATCCGCCCGATTTCGACTATGCGTTCAATCTCTCGTAT
GGGCAGGCGCATACGCGCAAGGTGCCGGCGCTGCAGCGGTTTCGCGAGCGCCTCGACGAGGCGACGCGCGAGCGGATGGC
CCGTGCTGGCGGGCCTTCGGGCTGA

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 21482.35 Da        Isoelectric Point: 8.7083

>AT109211 WP_103690443.1 NZ_CP031452:c1248624-1248034 [Burkholderia gladioli]
MKPISSNQATTTSLPPSALACSPGASLRRWRTLRRIKQEHAAALFGVSQSTISRWEAGTQAVSHEELRRIEACLSARLDS
AADRALERLVSHHTRPVHLVCDLTHRLLACSAPRAAEFAAPLSSLMGASLWPFATAEIVAREQSLRDAGWHDHPAPSIEF
DTGSNDSPQVPIRASRCRWTRFTLSDGTLARLVETL

Download         Length: 591 bp

>AT109211 NZ_CP031452:c1248624-1248034 [Burkholderia gladioli]
ATGAAACCGATATCGTCGAACCAGGCAACGACCACGTCCTTGCCGCCGTCCGCGCTGGCCTGTTCGCCGGGCGCGAGCTT
GCGTCGATGGCGCACGCTGCGCCGGATCAAGCAGGAACATGCAGCGGCGCTGTTCGGCGTATCGCAGTCGACGATATCGC
GCTGGGAAGCCGGCACGCAGGCGGTGTCGCACGAGGAACTGCGGCGCATCGAGGCCTGCTTGTCGGCGCGCCTCGACTCG
GCGGCGGATCGCGCGCTCGAGCGCCTCGTCAGCCATCACACCCGTCCCGTTCATCTCGTCTGCGACCTCACGCACCGGCT
GCTGGCCTGCTCCGCGCCGCGAGCCGCGGAGTTCGCGGCGCCGCTGTCGTCGCTGATGGGCGCGTCGCTCTGGCCGTTCG
CGACGGCCGAGATCGTGGCGCGCGAGCAGTCGTTGCGCGATGCGGGCTGGCACGATCATCCGGCGCCCTCGATCGAATTC
GATACCGGGTCCAACGATTCGCCTCAGGTGCCGATTCGTGCGAGCCGCTGCCGCTGGACGCGTTTCACCTTGTCCGACGG
GACGCTGGCGCGCCTGGTCGAAACGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A833Q958

Antitoxin

Source ID Structure

References