Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 61453..62102 Replicon plasmid unnamed1
Accession NZ_CP031451
Organism Burkholderia gladioli strain Lv-StA

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DX980_RS00305 Protein ID WP_160292568.1
Coordinates 61692..62102 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DX980_RS00300 Protein ID WP_160292567.1
Coordinates 61453..61695 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DX980_RS00270 (DX980_00265) 56546..56941 - 396 WP_236669212.1 hypothetical protein -
DX980_RS00275 59105..59440 + 336 WP_236669213.1 DUF4400 domain-containing protein -
DX980_RS00280 (DX980_00280) 59567..59789 + 223 Protein_55 IS5/IS1182 family transposase -
DX980_RS00285 (DX980_00285) 59764..60714 - 951 WP_160292565.1 site-specific integrase -
DX980_RS00290 (DX980_00290) 60840..61031 + 192 Protein_57 DUF2384 domain-containing protein -
DX980_RS00295 (DX980_00295) 61112..61213 + 102 Protein_58 GNAT family N-acetyltransferase -
DX980_RS00300 (DX980_00300) 61453..61695 + 243 WP_160292567.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DX980_RS00305 (DX980_00305) 61692..62102 + 411 WP_160292568.1 type II toxin-antitoxin system VapC family toxin Toxin
DX980_RS00310 (DX980_00310) 62520..62705 + 186 WP_160292569.1 hypothetical protein -
DX980_RS00315 (DX980_00315) 62846..63091 + 246 WP_160292666.1 type II toxin-antitoxin system ParD family antitoxin -
DX980_RS00320 (DX980_00320) 63081..63380 + 300 WP_160292570.1 type II toxin-antitoxin system RelE/ParE family toxin -
DX980_RS00325 (DX980_00325) 63400..63651 + 252 WP_160292571.1 hypothetical protein -
DX980_RS00330 (DX980_00330) 64058..64315 + 258 WP_160292572.1 hypothetical protein -
DX980_RS00335 (DX980_00335) 64974..65429 + 456 WP_160292573.1 hypothetical protein -
DX980_RS00340 (DX980_00340) 65433..65714 + 282 WP_160292574.1 type II toxin-antitoxin system RelE/ParE family toxin -
DX980_RS00345 (DX980_00345) 65901..66314 + 414 WP_160292575.1 DUF2384 domain-containing protein -
DX980_RS00350 (DX980_00350) 66542..66811 + 270 WP_160292576.1 DUF1778 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..191503 191503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(12-48)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14799.27 Da        Isoelectric Point: 7.1076

>T109210 WP_160292568.1 NZ_CP031451:61692-62102 [Burkholderia gladioli]
MTMYLLDTSILSNVMRDPRGACATRIGLTPPEHLCTSIVVAAELRFGVLKRGSSMLAQRVEQLLASLPVLPLQADADRCY
GRLRAELEKQGQLIGANDMLIAAHALAVEAVLVTDNTAEFARVAGLRVENWLRPTT

Download         Length: 411 bp

>T109210 NZ_CP031451:61692-62102 [Burkholderia gladioli]
ATGACGATGTACCTGCTGGACACCAGCATCTTGTCCAATGTGATGCGAGACCCGCGCGGCGCCTGCGCCACCCGAATCGG
ACTGACGCCGCCTGAGCACCTTTGCACCTCGATCGTCGTGGCGGCAGAGCTGCGCTTTGGCGTCTTGAAACGCGGTTCGT
CGATGCTCGCGCAGCGCGTCGAGCAACTTCTCGCGAGCTTGCCCGTGCTGCCGTTGCAGGCCGACGCCGACCGGTGCTAC
GGCCGATTGCGGGCCGAGCTCGAGAAGCAAGGCCAGTTGATCGGCGCCAACGACATGCTGATCGCCGCGCACGCGCTGGC
GGTCGAGGCCGTTCTGGTGACGGACAACACGGCCGAATTTGCCCGAGTTGCTGGGCTGCGGGTCGAAAACTGGTTGCGGC
CGACGACGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9261.53 Da        Isoelectric Point: 4.6234

>AT109210 WP_160292567.1 NZ_CP031451:61453-61695 [Burkholderia gladioli]
MPTHDIRHARLFRNGRSQAVRIPREFELAVSEVTIYREGQRLIIEPVPAAPLRELFAQWPPLDETFPDIENLSAEPVDIE

Download         Length: 243 bp

>AT109210 NZ_CP031451:61453-61695 [Burkholderia gladioli]
ATGCCCACTCACGATATTCGCCATGCCCGGTTGTTTCGCAACGGACGCAGCCAGGCCGTGCGGATTCCGCGCGAGTTCGA
ACTCGCTGTCTCCGAGGTCACCATCTACCGGGAAGGCCAGCGCCTGATCATCGAGCCCGTCCCGGCCGCGCCCTTGCGTG
AGCTGTTTGCCCAATGGCCCCCCCTGGATGAAACGTTTCCCGACATCGAGAACCTGTCGGCCGAACCGGTCGACATCGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References