Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1954352..1954956 Replicon chromosome
Accession NZ_CP031450
Organism Pseudomonas fluorescens strain SIK_W1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DXV65_RS09060 Protein ID WP_120447985.1
Coordinates 1954352..1954540 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DXV65_RS09065 Protein ID WP_120447986.1
Coordinates 1954552..1954956 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXV65_RS09035 1949432..1950004 + 573 WP_106804709.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
DXV65_RS09040 1949995..1950744 + 750 WP_106804708.1 phosphonate metabolism protein PhnP -
DXV65_RS09045 1951093..1952583 + 1491 WP_120447982.1 M10 family metallopeptidase C-terminal domain-containing protein -
DXV65_RS09050 1952573..1953454 - 882 WP_120447983.1 LysR family transcriptional regulator -
DXV65_RS09055 1953469..1954125 - 657 WP_120447984.1 AhpC/TSA family protein -
DXV65_RS09060 1954352..1954540 + 189 WP_120447985.1 type II toxin-antitoxin system HicA family toxin Toxin
DXV65_RS09065 1954552..1954956 + 405 WP_120447986.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DXV65_RS09070 1954963..1956159 - 1197 WP_083221339.1 MFS transporter -
DXV65_RS09075 1956338..1956952 + 615 WP_120447987.1 hypothetical protein -
DXV65_RS09085 1957080..1958084 - 1005 WP_065901602.1 sulfate ABC transporter substrate-binding protein -
DXV65_RS09090 1958190..1959014 - 825 WP_065901600.1 ion transporter -
DXV65_RS09095 1959046..1959921 - 876 WP_120447988.1 urea transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7233.45 Da        Isoelectric Point: 11.2000

>T109209 WP_120447985.1 NZ_CP031450:1954352-1954540 [Pseudomonas fluorescens]
VQSRLLIKELQEAGWLLDRVTGSHHIFTHRYNPYTIPVPHPKKDLPLGTVRSIRKRAGLFQF

Download         Length: 189 bp

>T109209 NZ_CP031450:1954352-1954540 [Pseudomonas fluorescens]
GTGCAAAGCAGGCTATTGATCAAGGAGCTGCAAGAGGCGGGTTGGTTGCTGGATCGGGTCACGGGCAGTCATCACATTTT
TACTCACCGCTATAACCCGTACACGATCCCGGTGCCGCACCCCAAGAAGGACCTGCCGCTGGGCACCGTCAGAAGCATCA
GGAAACGCGCCGGGCTGTTTCAGTTTTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14687.65 Da        Isoelectric Point: 4.6000

>AT109209 WP_120447986.1 NZ_CP031450:1954552-1954956 [Pseudomonas fluorescens]
MQYPICIEWGDDFTATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQEIAAEGGPIPMPTSVANHHAHEDYAGMGWGM
LELDVSPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRS

Download         Length: 405 bp

>AT109209 NZ_CP031450:1954552-1954956 [Pseudomonas fluorescens]
ATGCAATACCCAATCTGTATCGAATGGGGCGATGACTTTACCGCCACCGGTATTCAGATCCCCGATATTCCAGGCGCGGT
CACCGCCGGGGACAGTTTCGAAGAGGCGTACAACGCCGCCGTGGAAGTCGCGCACATCATGCTGCAAGAAATCGCCGCCG
AAGGTGGGCCGATTCCGATGCCCACGTCGGTGGCCAATCATCACGCCCATGAAGACTACGCCGGGATGGGCTGGGGCATG
CTCGAGCTGGACGTCTCGCCCTATCTGGGCAAGACCGAGAAGGTCAACGTGACCTTGCCCGGTTATGTCATCCAGCGCAT
CGACCGTTATGTGCGCGAGCACAAGGTCAAAAGCCGCTCGTCATTCCTGGCGGACGCGGCCTTGGAGAAGCTGGTGCGCT
CCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References