Detailed information of TA system TA109202

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/RHH(antitoxin)
• Location: 2672533..2673086
• Replicon: chromosome
• Accession: NZ_CP031449
• Organism: Pseudomonas aeruginosa strain 97

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q88JZ3
• Locus tag: CP913_RS13280
• Protein ID: WP_010953434.1
• Coordinates: 2672793..2673086 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CP913_RS13275
• Protein ID: WP_096862010.1
• Coordinates: 2672533..2672805 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CP913_RS13245	2667572..2668579	-	1008	WP_096862006.1	YqaJ viral recombinase family protein	-
CP913_RS13250	2668736..2668966	+	231	WP_096862007.1	antitoxin	-
CP913_RS13255	2668966..2669370	+	405	WP_020308731.1	tRNA(fMet)-specific endonuclease VapC	-
CP913_RS13260	2669457..2670425	-	969	WP_096862008.1	DUF932 domain-containing protein	-
CP913_RS13270	2671183..2672405	+	1223	WP_096862009.1	IS3 family transposase	-
CP913_RS13275	2672533..2672805	+	273	WP_096862010.1	CopG family ribbon-helix-helix protein	Antitoxin
CP913_RS13280	2672793..2673086	+	294	WP_010953434.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CP913_RS13285	2673080..2674489	-	1410	WP_096862011.1	site-specific integrase	-
CP913_RS13290	2674812..2675924	-	1113	WP_012613967.1	phage integrase Arm DNA-binding domain-containing protein	-
CP913_RS13295	2675924..2676139	-	216	WP_023106402.1	hypothetical protein	-
CP913_RS13300	2676213..2676599	-	387	WP_031631092.1	hypothetical protein	-
CP913_RS13305	2676711..2677013	-	303	Protein_2561	hypothetical protein	-
CP913_RS13310	2676993..2677442	+	450	Protein_2562	phage minor tail protein L	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	sul1 / aadA11 / qnrVC1 / blaDIM-1	-	2622499..2683476	60977

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11155.61 Da
• Isoelectric Point: 5.9081

>T109202 WP_010953434.1 NZ_CP031449:2672793-2673086 [Pseudomonas aeruginosa]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Nucleotide

• Length: 294 bp

>T109202 NZ_CP031449:2672793-2673086 [Pseudomonas aeruginosa]
GTGCCACGACTGATCGTCACGGAAGGCGCGGCGAAGGGCCTGGAGCGTTGCCGGCGATTTCTCTCCGATAAAGATCCGCA
GGTCGCGCGCCGTGCTGCACAGGCAATCGAGCGCCAATTCGCTCGATTGGAGGAAAGTCCGGAAGTAGGGCGTCCATTTC
CAGATCTGCCAGAGCTGCGTGAGCTCATCATTGAGTTTGGTGACTCAGGTTACGTCGCGTTGTACCGCTATGAGCGCGCA
GATGACACCGCCTATGTCTTGGCCTTTCGCCATCAAAAAGAAGCTGGCTACTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10494.66 Da
• Isoelectric Point: 6.7193

>AT109202 WP_096862010.1 NZ_CP031449:2672533-2672805 [Pseudomonas aeruginosa]
MATSIKIDDKLKGRIQQLASQRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGRHLTSQETRTWLGSWGTD
TEAELPKCHD

Nucleotide

• Length: 273 bp

>AT109202 NZ_CP031449:2672533-2672805 [Pseudomonas aeruginosa]
ATGGCCACTTCCATCAAAATTGATGACAAGCTAAAAGGCCGCATTCAGCAGTTGGCGAGCCAACGCCAGCGCTCGTCTCA
CTGGATCATGCGCGAGGCAATCACCCAGTACGTCGAGCGTGAGGAGGCCCGTGAGAGCTTCAAGCAGGAAGCCCTGGCAT
CGTGGGCGGCATATCAGGAAACCGGACGGCATTTGACCAGCCAAGAAACTCGGACCTGGCTCGGTAGCTGGGGAACAGAT
ACTGAGGCAGAGTTGCCCAAGTGCCACGACTGA

Structures

Toxin

• AlphaFold DB: A0A2W5CNE8