Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2668736..2669370 Replicon chromosome
Accession NZ_CP031449
Organism Pseudomonas aeruginosa strain 97

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CP913_RS13255 Protein ID WP_020308731.1
Coordinates 2668966..2669370 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CP913_RS13250 Protein ID WP_096862007.1
Coordinates 2668736..2668966 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP913_RS13225 2664780..2665766 + 987 WP_175425918.1 hypothetical protein -
CP913_RS13235 2666061..2666558 - 498 WP_017940311.1 DNA repair protein RadC -
CP913_RS13240 2666530..2667480 - 951 WP_096862005.1 hydrolase or metal-binding protein -
CP913_RS13245 2667572..2668579 - 1008 WP_096862006.1 YqaJ viral recombinase family protein -
CP913_RS13250 2668736..2668966 + 231 WP_096862007.1 antitoxin Antitoxin
CP913_RS13255 2668966..2669370 + 405 WP_020308731.1 tRNA(fMet)-specific endonuclease VapC Toxin
CP913_RS13260 2669457..2670425 - 969 WP_096862008.1 DUF932 domain-containing protein -
CP913_RS13270 2671183..2672405 + 1223 WP_096862009.1 IS3 family transposase -
CP913_RS13275 2672533..2672805 + 273 WP_096862010.1 CopG family ribbon-helix-helix protein -
CP913_RS13280 2672793..2673086 + 294 WP_010953434.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island sul1 / aadA11 / qnrVC1 / blaDIM-1 - 2622499..2683476 60977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-35)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14995.23 Da        Isoelectric Point: 7.2774

>T109201 WP_020308731.1 NZ_CP031449:2668966-2669370 [Pseudomonas aeruginosa]
MLKYMLDTNMCIFTIKNRPEQVREAFKRHSGQLSISTVTLMELIYGAEKSANPERNLADVEGFAARLEVLPYDAQAAAHS
GQLRAELARIGKPIGPYDQMIAGHARAQGLILVTNNLREFERVPGLRVEDWVNA

Download         Length: 405 bp

>T109201 NZ_CP031449:2668966-2669370 [Pseudomonas aeruginosa]
ATGCTGAAGTACATGCTTGATACCAACATGTGCATTTTCACGATCAAGAATCGCCCTGAGCAGGTGCGGGAAGCCTTCAA
GCGCCATTCAGGCCAGCTGAGCATCAGCACTGTCACCCTGATGGAGCTTATTTACGGCGCCGAGAAGTCCGCTAATCCCG
AGCGTAATCTGGCGGACGTTGAAGGTTTCGCTGCGCGCTTGGAAGTACTGCCTTACGACGCTCAGGCAGCGGCTCATTCC
GGGCAATTGCGAGCTGAGTTGGCTCGTATCGGCAAGCCTATTGGCCCGTATGATCAGATGATTGCAGGACACGCACGTGC
CCAGGGACTGATTCTGGTCACGAATAATCTTCGTGAGTTCGAGCGAGTCCCAGGTTTGCGCGTCGAGGATTGGGTGAACG
CCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8460.46 Da        Isoelectric Point: 4.2683

>AT109201 WP_096862007.1 NZ_CP031449:2668736-2668966 [Pseudomonas aeruginosa]
MEQGAVFQSNRSQAVRLPKAVALPEDVKRVDVVVVGRARIITPAGEAWDVWFDGEGVTADYMADREQPVDQERDAF

Download         Length: 231 bp

>AT109201 NZ_CP031449:2668736-2668966 [Pseudomonas aeruginosa]
ATGGAACAAGGTGCAGTTTTTCAGAGCAACCGCAGTCAGGCGGTGCGATTGCCCAAGGCGGTTGCGCTGCCTGAGGATGT
GAAGCGGGTGGATGTAGTAGTAGTTGGTCGAGCTCGAATCATCACGCCGGCAGGCGAGGCCTGGGACGTCTGGTTCGATG
GCGAAGGTGTGACCGCTGACTACATGGCGGATCGCGAGCAGCCTGTAGATCAAGAGCGGGATGCGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References