Detailed information of TA system TA109199

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1603729..1604440
• Replicon: chromosome
• Accession: NZ_CP031449
• Organism: Pseudomonas aeruginosa strain 97

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CP913_RS07880
• Protein ID: WP_033971890.1
• Coordinates: 1604258..1604440 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CP913_RS07875
• Protein ID: WP_058168140.1
• Coordinates: 1603729..1604211 (-)
• Length: 161 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CP913_RS07825	1599393..1599593	+	201	WP_015649348.1	regulatory protein cro	-
CP913_RS07830	1599705..1599926	+	222	WP_021205584.1	hypothetical protein	-
CP913_RS07840	1600299..1601015	+	717	WP_034066246.1	helix-turn-helix domain-containing protein	-
CP913_RS07845	1601012..1601695	+	684	WP_094202336.1	hypothetical protein	-
CP913_RS07850	1601692..1601898	+	207	WP_003159465.1	hypothetical protein	-
CP913_RS07855	1601895..1602266	+	372	WP_094202337.1	recombinase	-
CP913_RS07860	1602263..1602610	+	348	WP_058168138.1	RusA family crossover junction endodeoxyribonuclease	-
CP913_RS07865	1602607..1602906	+	300	WP_033950491.1	hypothetical protein	-
CP913_RS07870	1602944..1603618	+	675	WP_021205614.1	hypothetical protein	-
CP913_RS07875	1603729..1604211	-	483	WP_058168140.1	transcriptional regulator	Antitoxin
CP913_RS07880	1604258..1604440	-	183	WP_033971890.1	type II toxin-antitoxin system HicA family toxin	Toxin
CP913_RS07885	1604640..1604972	+	333	WP_043494869.1	phage holin, lambda family	-
CP913_RS07890	1604969..1605586	+	618	WP_073665565.1	glycoside hydrolase family 19 protein	-
CP913_RS07895	1605583..1605825	+	243	WP_023875728.1	hypothetical protein	-
CP913_RS07900	1605822..1606292	+	471	WP_096861740.1	lysis system i-spanin subunit Rz	-
CP913_RS07905	1606289..1607032	+	744	WP_003159066.1	hypothetical protein	-
CP913_RS07910	1607152..1607697	+	546	WP_010791974.1	terminase small subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1580146..1631340	51194

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (7-78)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6776.89 Da
• Isoelectric Point: 11.0775

>T109199 WP_033971890.1 NZ_CP031449:c1604440-1604258 [Pseudomonas aeruginosa]
MKFSEFRRWLKAQGVTFEAGKGSHFKITAPNGKQTTFADHGTKEMPEPTRKAIIKQLGLK

Nucleotide

• Length: 183 bp

>T109199 NZ_CP031449:c1604440-1604258 [Pseudomonas aeruginosa]
ATGAAGTTCAGCGAATTCAGACGATGGTTGAAGGCCCAAGGGGTGACCTTCGAAGCCGGCAAGGGAAGCCACTTCAAGAT
CACCGCCCCGAACGGCAAACAGACCACCTTCGCGGACCACGGAACTAAGGAAATGCCAGAACCGACCCGCAAGGCGATCA
TCAAGCAACTGGGGCTCAAATGA

Antitoxin

Protein

• Length: 161 a.a.
• Molecular weight: 18149.69 Da
• Isoelectric Point: 5.0964

>AT109199 WP_058168140.1 NZ_CP031449:c1604211-1603729 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSYGDDKAHAISEAVDAIESTLSLYVDQRREIPAASQAQPGERVIHLPAVTVA
KIALWNEMVRRDMRKADLCRLLGIAQTQGDRLVDFLHNTKMEALENALDFLGLRLRVQIERDKDVERKMAEPPERGKLRA

Nucleotide

• Length: 483 bp

>AT109199 NZ_CP031449:c1604211-1603729 [Pseudomonas aeruginosa]
ATGTACGACTATGCAATCCGTTTCGAACAGGACGATAGCGCTCCTGGCGTCGCCGTTTTCTGCAGAGACCTGCCGGAACT
GAACAGCTACGGTGACGATAAGGCCCATGCAATCAGCGAGGCGGTTGACGCCATCGAGTCAACCCTCTCGCTGTACGTTG
ATCAGCGCCGAGAAATCCCCGCAGCCAGCCAGGCGCAACCAGGCGAGCGCGTGATCCATCTGCCGGCGGTTACAGTTGCG
AAGATCGCGCTCTGGAACGAAATGGTCCGGCGAGATATGCGAAAGGCCGACCTCTGCAGGCTGCTCGGTATCGCACAAAC
TCAGGGCGACAGGCTCGTTGACTTCCTCCACAACACCAAAATGGAAGCGCTGGAAAATGCGCTTGATTTTCTCGGCCTTC
GGCTGCGAGTTCAGATCGAGCGGGACAAAGACGTAGAGCGAAAAATGGCGGAACCGCCGGAGCGTGGAAAGCTCAGGGCC
TGA