Detailed information of TA system TA109197

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 163566..164071
• Replicon: chromosome
• Accession: NZ_CP031449
• Organism: Pseudomonas aeruginosa strain 97

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: CP913_RS00745
• Protein ID: WP_034037564.1
• Coordinates: 163566..163847 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: CP913_RS00750
• Protein ID: WP_003083775.1
• Coordinates: 163844..164071 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CP913_RS00720	158817..160166	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
CP913_RS00725	160215..160901	+	687	WP_003083762.1	FadR family transcriptional regulator	-
CP913_RS00730	161002..161736	+	735	WP_003117208.1	GntR family transcriptional regulator	-
CP913_RS00735	161940..162326	+	387	WP_014602345.1	aegerolysin family protein	-
CP913_RS00740	162358..163266	-	909	WP_016561475.1	LysR family transcriptional regulator	-
CP913_RS00745	163566..163847	-	282	WP_034037564.1	type II toxin-antitoxin system toxin ParE	Toxin
CP913_RS00750	163844..164071	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
CP913_RS00755	164247..164867	-	621	WP_003101226.1	hypothetical protein	-
CP913_RS00760	164968..165468	+	501	WP_003101228.1	LEA type 2 family protein	-
CP913_RS00765	165541..165882	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
CP913_RS00770	165964..167391	-	1428	WP_003083784.1	GABA permease	-
CP913_RS00775	167560..169053	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10458.20 Da
• Isoelectric Point: 10.0435

>T109197 WP_034037564.1 NZ_CP031449:c163847-163566 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLPLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T109197 NZ_CP031449:c163847-163566 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGCCCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT109197 WP_003083775.1 NZ_CP031449:c164071-163844 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT109197 NZ_CP031449:c164071-163844 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1C7BDS9