109194

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3502303..3502954 Replicon chromosome
Accession NZ_CP031444
Organism Acinetobacter baumannii strain MDR-UNC

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag DYB08_RS17240 Protein ID WP_000838146.1
Coordinates 3502303..3502485 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag DYB08_RS17245 Protein ID WP_000966689.1
Coordinates 3502550..3502954 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DYB08_RS17195 3497560..3498225 + 666 WP_000767881.1 stress-responsive nuclear envelope protein -
DYB08_RS17200 3498230..3498619 + 390 WP_000008492.1 hypothetical protein -
DYB08_RS17205 3498621..3498989 + 369 WP_000524231.1 hypothetical protein -
DYB08_RS17210 3498998..3499402 + 405 WP_000248323.1 hypothetical protein -
DYB08_RS17215 3499374..3499742 + 369 WP_000539752.1 hypothetical protein -
DYB08_RS17220 3499744..3500142 + 399 WP_001132270.1 hypothetical protein -
DYB08_RS17225 3500144..3500356 + 213 WP_000121166.1 hypothetical protein -
DYB08_RS17230 3500464..3501393 + 930 WP_000094299.1 hypothetical protein -
DYB08_RS17235 3501438..3501971 + 534 WP_001185622.1 hypothetical protein -
DYB08_RS17240 3502303..3502485 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
DYB08_RS17245 3502550..3502954 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DYB08_RS17250 3503035..3503436 + 402 WP_000720591.1 hypothetical protein -
DYB08_RS17255 3503497..3507462 + 3966 WP_000191304.1 tape measure protein -
DYB08_RS17260 3507580..3507921 + 342 WP_001281459.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3452498..3531018 78520


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T109194 WP_000838146.1 NZ_CP031444:3502303-3502485 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T109194 NZ_CP031444:3502303-3502485 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT109194 WP_000966689.1 NZ_CP031444:3502550-3502954 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT109194 NZ_CP031444:3502550-3502954 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References