Detailed information of TA system TA109192

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2552951..2553926
• Replicon: chromosome
• Accession: NZ_CP031443
• Organism: Bacillus mobilis strain ML-A2C4

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: MLA2C4_RS13275
• Protein ID: WP_002071740.1
• Coordinates: 2552951..2553688 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: R8HWP4
• Locus tag: MLA2C4_RS13280
• Protein ID: WP_000588712.1
• Coordinates: 2553801..2553926 (+)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MLA2C4_RS13250	2548148..2548870	+	723	WP_120450168.1	class I SAM-dependent methyltransferase	-
MLA2C4_RS13255	2548978..2549385	+	408	WP_120450169.1	VOC family protein	-
MLA2C4_RS13260	2549435..2551120	-	1686	WP_120450171.1	alpha-keto acid decarboxylase family protein	-
MLA2C4_RS13265	2551228..2551710	+	483	WP_000191903.1	MarR family winged helix-turn-helix transcriptional regulator	-
MLA2C4_RS13270	2551877..2552614	+	738	WP_000594143.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
MLA2C4_RS13275	2552951..2553688	+	738	WP_002071740.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
MLA2C4_RS13280	2553801..2553926	+	126	WP_000588712.1	hypothetical protein	Antitoxin
MLA2C4_RS13285	2554207..2554482	-	276	WP_001041557.1	hypothetical protein	-
MLA2C4_RS28680	2554509..2555303	-	795	WP_162937119.1	hypothetical protein	-
MLA2C4_RS13290	2555364..2556344	-	981	WP_098258776.1	WXG100 family type VII secretion target	-
MLA2C4_RS28685	2556676..2556852	+	177	WP_088080047.1	hypothetical protein	-
MLA2C4_RS13295	2556994..2558463	+	1470	WP_120450173.1	beta-Ala-His dipeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2492074..2562805	70731

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (9-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28381.13 Da
• Isoelectric Point: 8.3034

>T109192 WP_002071740.1 NZ_CP031443:2552951-2553688 [Bacillus mobilis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAMFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKMVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T109192 NZ_CP031443:2552951-2553688 [Bacillus mobilis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTCGTTCTTGTGTTCTTTTACTGGAGAAACGA
AGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAACCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATCGCATTT
ATTTTAACACCTAATATTTCCGAAATATGGGGAGCGAAATTTAGCGATATTGGCAAGACTGTTCAATCGATAAAACGGTC
TTTAATTGCTTCTAAAGCAAGAGGGGAAATATATACAACAATTATTCAAAATGTCAATCCAGCAATGTTCGGTACAATGG
AATGGCATACGGAAGAAGAGTATACAAAGAGCTTAAACGCATTTTTAGATTCGTATGGAGAAAAGATTGGAGCGAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTATTATCGTTCCGTTAGA
ACACATTGAGCAACTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATAATACCAGCAAAAATGGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4970.40 Da
• Isoelectric Point: 3.9150

>AT109192 WP_000588712.1 NZ_CP031443:2553801-2553926 [Bacillus mobilis]
MIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Nucleotide

• Length: 126 bp

>AT109192 NZ_CP031443:2553801-2553926 [Bacillus mobilis]
ATGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A366GQT1