Detailed information of TA system TA109186

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 260754..261304
• Replicon: chromosome
• Accession: NZ_CP031422
• Organism: Microbacterium oxydans strain HG3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0M3D9A7
• Locus tag: CVS54_RS01190
• Protein ID: WP_046748149.1
• Coordinates: 261026..261304 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CVS54_RS01185
• Protein ID: WP_171011062.1
• Coordinates: 260754..261029 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CVS54_RS01160	255888..256658	+	771	WP_046748144.1	SDR family oxidoreductase	-
CVS54_RS01165	256655..257731	+	1077	WP_127011542.1	hypothetical protein	-
CVS54_RS01170	257733..258524	+	792	WP_127011543.1	SDR family oxidoreductase	-
CVS54_RS01175	258533..259348	-	816	WP_046748147.1	hypothetical protein	-
CVS54_RS01180	259468..260664	+	1197	WP_127011544.1	DNA polymerase IV	-
CVS54_RS01185	260754..261029	+	276	WP_171011062.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CVS54_RS01190	261026..261304	+	279	WP_046748149.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CVS54_RS01195	261330..261680	-	351	WP_046748150.1	nuclear transport factor 2 family protein	-
CVS54_RS01200	261673..262422	-	750	WP_046748151.1	SDR family oxidoreductase	-
CVS54_RS01205	262449..263705	-	1257	WP_127011545.1	sodium:proton exchanger	-
CVS54_RS01210	264065..265039	+	975	WP_127011546.1	C-terminal binding protein	-
CVS54_RS01215	265054..265908	+	855	WP_127011547.1	fumarylacetoacetate hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10368.98 Da
• Isoelectric Point: 9.8420

>T109186 WP_046748149.1 NZ_CP031422:261026-261304 [Microbacterium oxydans]
VTSEAYEVRLTGPAVRALHRLEPKLADAVLRFLEGPLAENPMRTTKALGAELDGQRSGYVGIAYRVVVRVDEEARTVYVM
RIAHRADVYRRM

Nucleotide

• Length: 279 bp

>T109186 NZ_CP031422:261026-261304 [Microbacterium oxydans]
GTGACGTCGGAGGCCTACGAGGTCCGGCTCACCGGGCCTGCTGTTCGGGCGTTGCATCGGCTGGAGCCGAAGCTGGCCGA
CGCAGTGCTCCGGTTCCTCGAGGGTCCGCTTGCGGAGAACCCCATGCGCACCACCAAAGCGCTCGGTGCGGAACTCGACG
GCCAGCGCAGCGGATACGTCGGCATCGCGTATCGCGTCGTGGTCCGCGTCGACGAGGAAGCTCGTACGGTCTATGTGATG
CGCATCGCCCACCGCGCAGACGTGTATCGGAGGATGTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10083.27 Da
• Isoelectric Point: 4.3195

>AT109186 WP_171011062.1 NZ_CP031422:260754-261029 [Microbacterium oxydans]
MFMQSVSVSEAKDRFSQLVESVDTTHEAVTITRHGRPAVVMLSVDDLEALQETLALLQDPHHLDEVVEADDDIAGGRTLS
LAEVREQLGRR

Nucleotide

• Length: 276 bp

>AT109186 NZ_CP031422:260754-261029 [Microbacterium oxydans]
ATGTTCATGCAGTCAGTGTCGGTCAGTGAGGCAAAGGACAGGTTCTCGCAGCTGGTGGAGTCCGTCGACACCACGCACGA
GGCGGTGACGATCACGCGCCACGGGCGCCCGGCGGTCGTCATGCTGAGCGTGGACGACCTGGAGGCGCTGCAGGAGACCC
TTGCGCTGCTGCAAGATCCGCATCATCTCGACGAAGTGGTGGAAGCTGACGACGATATCGCTGGCGGGCGGACGTTGAGC
CTTGCTGAGGTGCGAGAGCAGCTGGGCCGCCGGTGA

Structures

Toxin

• AlphaFold DB: A0A0M3D9A7