Detailed information of TA system TA109182

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3252665..3253273
• Replicon: chromosome
• Accession: NZ_CP031415
• Organism: Saccharospirillum mangrovi strain HK-33

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: DW349_RS15190
• Protein ID: WP_108124368.1
• Coordinates: 3253070..3253273 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: DW349_RS15185
• Protein ID: WP_108124033.1
• Coordinates: 3252665..3253066 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DW349_RS15175	3249579..3250976	+	1398	WP_108124031.1	HDOD domain-containing protein	-
DW349_RS15180	3251097..3252554	-	1458	WP_108124032.1	beta-Ala-His dipeptidase	-
DW349_RS15185	3252665..3253066	-	402	WP_108124033.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DW349_RS15190	3253070..3253273	-	204	WP_108124368.1	type II toxin-antitoxin system HicA family toxin	Toxin
DW349_RS15195	3253564..3255375	+	1812	WP_108124034.1	DEAD/DEAH box helicase	-
DW349_RS15200	3255494..3255673	-	180	WP_108124035.1	hypothetical protein	-
DW349_RS15205	3255673..3256482	-	810	WP_108124369.1	indole-3-glycerol phosphate synthase TrpC	-
DW349_RS15210	3256506..3257543	-	1038	WP_108124036.1	anthranilate phosphoribosyltransferase	-
DW349_RS15215	3257607..3258206	-	600	WP_108124370.1	aminodeoxychorismate/anthranilate synthase component II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (17-64)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7867.10 Da
• Isoelectric Point: 11.6247

>T109182 WP_108124368.1 NZ_CP031415:c3253273-3253070 [Saccharospirillum mangrovi]
MNSVAIIKRLFVDQKQREGWRRVGGKGDHSKFKHPDKPGHVVVPHPRKDLPIGTVRNIYRQAGWEWR

Nucleotide

• Length: 204 bp

>T109182 NZ_CP031415:c3253273-3253070 [Saccharospirillum mangrovi]
ATGAATAGTGTAGCCATCATTAAGCGACTCTTTGTAGATCAAAAACAACGCGAAGGATGGCGGCGGGTAGGCGGCAAGGG
TGATCACTCGAAATTCAAACACCCGGACAAGCCCGGCCACGTCGTAGTGCCACATCCACGGAAGGATTTACCGATCGGTA
CAGTGCGCAATATATACCGCCAGGCCGGCTGGGAGTGGAGGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14610.39 Da
• Isoelectric Point: 4.3221

>AT109182 WP_108124033.1 NZ_CP031415:c3253066-3252665 [Saccharospirillum mangrovi]
MLYPIYIHPGNATEAHGVTLPDFPGCFSAADDWEAIPAAVQETIELWFEGEDIEVPDPTPLETLARDDAYEGGVWMLVDI
DTTRLTGPSKRINLTVPVGALRTIDAAARVHHESRSAFLTRAGLALARREQNQ

Nucleotide

• Length: 402 bp

>AT109182 NZ_CP031415:c3253066-3252665 [Saccharospirillum mangrovi]
ATGCTTTATCCAATCTATATTCATCCCGGTAACGCTACGGAAGCACACGGAGTGACGCTGCCTGATTTTCCGGGTTGTTT
CTCCGCTGCAGACGACTGGGAAGCCATCCCAGCCGCTGTGCAGGAAACGATAGAACTGTGGTTTGAAGGGGAAGATATCG
AGGTACCCGATCCCACACCGCTGGAAACACTGGCACGGGACGATGCGTATGAAGGCGGTGTCTGGATGTTGGTCGATATT
GATACCACTCGGCTGACCGGGCCATCCAAACGCATCAATCTGACGGTGCCAGTGGGGGCGTTGCGAACCATTGACGCGGC
CGCCCGGGTGCATCACGAAAGCCGCTCCGCCTTTCTGACGCGGGCCGGTTTGGCCTTGGCCCGGCGTGAACAGAATCAAT
GA