Detailed information of TA system TA109178

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 6340621..6341251
• Replicon: chromosome
• Accession: NZ_CP031396
• Organism: Pseudomonas protegens strain FD6

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: DWF74_RS28855
• Protein ID: WP_108543126.1
• Coordinates: 6341072..6341251 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: DWF74_RS28850
• Protein ID: WP_102864418.1
• Coordinates: 6340621..6341028 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DWF74_RS28830	6337343..6338398	+	1056	WP_041117702.1	ABC transporter substrate-binding protein	-
DWF74_RS28835	6338410..6338859	+	450	WP_115582503.1	peptide-methionine (S)-S-oxide reductase MsrA	-
DWF74_RS28840	6339058..6339330	-	273	WP_102864417.1	hypothetical protein	-
DWF74_RS28850	6340621..6341028	-	408	WP_102864418.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DWF74_RS28855	6341072..6341251	-	180	WP_108543126.1	type II toxin-antitoxin system HicA family toxin	Toxin
DWF74_RS28860	6341380..6342801	-	1422	WP_115582253.1	efflux transporter outer membrane subunit	-
DWF74_RS28865	6342785..6343951	-	1167	WP_115582254.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6685.92 Da
• Isoelectric Point: 11.1799

>T109178 WP_108543126.1 NZ_CP031396:c6341251-6341072 [Pseudomonas protegens]
VNIRQLIAQIEADGWYLVRVKGSHHHFKHPTKPGLVTIPHPKKDLLAKTVSSILKQARL

Nucleotide

• Length: 180 bp

>T109178 NZ_CP031396:c6341251-6341072 [Pseudomonas protegens]
GTGAACATCCGGCAACTCATCGCCCAGATCGAAGCAGATGGTTGGTATCTGGTCAGGGTCAAGGGCAGTCACCACCACTT
CAAACACCCAACCAAGCCAGGCCTGGTCACCATTCCCCATCCCAAAAAAGATCTACTGGCCAAAACGGTAAGCAGCATAT
TGAAACAAGCCCGGCTCTAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14752.81 Da
• Isoelectric Point: 4.5801

>AT109178 WP_102864418.1 NZ_CP031396:c6341028-6340621 [Pseudomonas protegens]
MLYPIAILPGDDQHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHLELLAEEGAAIPTARTVTLHAANPQYQGCTWAV
IDIDITRYMGKAEKLNITLPGYLLNRIDEYVKHHPEQKSRSGFLAQAALRVLQGV

Nucleotide

• Length: 408 bp

>AT109178 NZ_CP031396:c6341028-6340621 [Pseudomonas protegens]
ATGCTCTATCCCATTGCCATTCTCCCCGGTGACGACCAACACGCCTGGGGTGTGGAAGTACCCGATATTCCTGGCTGCTT
CTCCGCCGGCGACGACCTCGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAAGGCCACCTGGAATTACTGGCCGAAG
AAGGAGCAGCCATTCCCACAGCACGCACAGTGACCCTCCACGCCGCCAATCCCCAGTATCAAGGCTGCACTTGGGCCGTG
ATTGATATCGACATCACTCGCTACATGGGCAAGGCGGAAAAACTCAACATCACGCTGCCGGGCTATTTGCTGAATCGAAT
TGATGAATATGTGAAACATCATCCGGAACAGAAAAGCCGATCGGGCTTTTTGGCTCAGGCCGCGTTGAGGGTCTTGCAGG
GCGTTTGA