Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5900127..5900749 Replicon chromosome
Accession NZ_CP031396
Organism Pseudomonas protegens strain FD6

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DWF74_RS26730 Protein ID WP_042942436.1
Coordinates 5900567..5900749 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DWF74_RS26725 Protein ID WP_115582025.1
Coordinates 5900127..5900528 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DWF74_RS26705 5895736..5896605 + 870 WP_115582022.1 AraC family transcriptional regulator -
DWF74_RS26710 5896674..5896928 + 255 WP_060838485.1 hypothetical protein -
DWF74_RS26715 5896977..5897333 - 357 WP_115582023.1 hypothetical protein -
DWF74_RS26720 5897801..5899426 + 1626 WP_115582024.1 methyl-accepting chemotaxis protein -
DWF74_RS26725 5900127..5900528 - 402 WP_115582025.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DWF74_RS26730 5900567..5900749 - 183 WP_042942436.1 type II toxin-antitoxin system HicA family toxin Toxin
DWF74_RS26735 5901019..5901564 + 546 WP_115582026.1 hypothetical protein -
DWF74_RS26740 5901716..5902291 - 576 WP_115582027.1 hypothetical protein -
DWF74_RS26745 5902827..5903345 + 519 WP_080966932.1 sugar O-acetyltransferase -
DWF74_RS26750 5903366..5904604 + 1239 WP_041117182.1 aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6836.02 Da        Isoelectric Point: 11.5631

>T109177 WP_042942436.1 NZ_CP031396:c5900749-5900567 [Pseudomonas protegens]
VQSRQLIKELEAAGWVLERVTGSHHLFQHPYRPHTVPVPHPKKDLPRGTVRAIRKLAGLL

Download         Length: 183 bp

>T109177 NZ_CP031396:c5900749-5900567 [Pseudomonas protegens]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCGCGGGATGGGTGCTGGAGCGAGTCACTGGCAGCCATCATCTGTT
CCAGCATCCCTACAGGCCACACACCGTTCCAGTGCCTCACCCGAAGAAGGATCTGCCCCGGGGAACGGTCAGGGCCATCA
GGAAACTGGCCGGGCTGCTTTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14614.61 Da        Isoelectric Point: 5.5455

>AT109177 WP_115582025.1 NZ_CP031396:c5900528-5900127 [Pseudomonas protegens]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFETAYSAAIEIAHVMLEERARAGQAIPLPSPTSKHRTHPDFAGMGWGL
LEIDITPYLGKTEKVNVTLPGYVIQQIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp

>AT109177 NZ_CP031396:c5900528-5900127 [Pseudomonas protegens]
GTGCAATATCCCATCTGCATCGAGTGGGGCGACGAACACACCGCCACCGGCATCCAGATTCCCGACATCCCCGGCGCCGT
CACCGCGGGCGACACCTTCGAAACCGCCTATAGCGCGGCCATCGAGATTGCCCACGTTATGCTCGAAGAACGGGCCCGAG
CCGGGCAGGCCATTCCCCTGCCCTCACCCACCAGCAAACACCGCACCCACCCCGATTTCGCGGGCATGGGCTGGGGCCTG
CTGGAGATCGACATCACGCCTTACCTGGGCAAGACCGAGAAGGTCAACGTGACCTTGCCGGGGTATGTGATTCAGCAGAT
CGACCGCTTTGTCCGCGAGCACAACATCAAGAGCCGCTCGTCCTTCCTGGCCGATGCGGCAATGGAAAAGCTCGGGCGCT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References