Detailed information of TA system TA109174

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3714254..3714770
• Replicon: chromosome
• Accession: NZ_CP031396
• Organism: Pseudomonas protegens strain FD6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DWF74_RS16755
• Protein ID: WP_102862559.1
• Coordinates: 3714489..3714770 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0D6BA30
• Locus tag: DWF74_RS16750
• Protein ID: WP_060841856.1
• Coordinates: 3714254..3714499 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DWF74_RS16730	3709337..3711535	-	2199	WP_115581330.1	outer membrane assembly lipoprotein YfiO	-
DWF74_RS16735	3711744..3713351	+	1608	WP_115581331.1	glycosyltransferase family 39 protein	-
DWF74_RS16740	3713468..3713929	+	462	WP_102862557.1	YbaK/EbsC family protein	-
DWF74_RS16745	3713944..3714189	+	246	WP_102862558.1	DUF2789 domain-containing protein	-
DWF74_RS16750	3714254..3714499	+	246	WP_060841856.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DWF74_RS16755	3714489..3714770	+	282	WP_102862559.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DWF74_RS16760	3714913..3715341	+	429	WP_102862560.1	winged helix DNA-binding protein	-
DWF74_RS16765	3715338..3717425	+	2088	WP_115581332.1	FUSC family protein	-
DWF74_RS16770	3717422..3717631	+	210	WP_011058538.1	DUF1656 domain-containing protein	-
DWF74_RS16775	3717628..3718518	+	891	WP_102862562.1	HlyD family secretion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10825.74 Da
• Isoelectric Point: 10.3689

>T109174 WP_102862559.1 NZ_CP031396:3714489-3714770 [Pseudomonas protegens]
MTYRLEFLPSAHKEWSKLGHTLREQFKKKLAERLEVPRIPADALHGLADCYKIKLKASGYRLVYQVIEERVVVCVVAVGK
RERGAVYEQARKR

Nucleotide

• Length: 282 bp

>T109174 NZ_CP031396:3714489-3714770 [Pseudomonas protegens]
ATGACTTATAGGCTTGAGTTTCTGCCTTCGGCACACAAGGAATGGAGCAAGTTGGGGCATACGCTTCGAGAGCAATTCAA
GAAAAAGCTCGCCGAACGGCTTGAGGTGCCGCGAATCCCCGCTGATGCCCTGCACGGGCTTGCCGATTGCTACAAAATCA
AACTCAAGGCTTCGGGCTACCGGTTGGTATATCAAGTGATCGAAGAACGCGTCGTGGTTTGCGTGGTTGCGGTAGGCAAG
CGCGAGCGTGGCGCTGTGTACGAGCAGGCCAGGAAACGCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8727.04 Da
• Isoelectric Point: 4.5164

>AT109174 WP_060841856.1 NZ_CP031396:3714254-3714499 [Pseudomonas protegens]
MQSILADKAVSVSELKKNPSAVLSGAQGGPVAVLNHNRVMGYMVPAEVFEALMERLDDLELAEIVRARSHETPVPVSLDD
L

Nucleotide

• Length: 246 bp

>AT109174 NZ_CP031396:3714254-3714499 [Pseudomonas protegens]
ATGCAAAGTATTCTGGCTGACAAAGCCGTCAGCGTATCTGAGTTGAAGAAAAACCCTTCTGCCGTCTTGAGTGGTGCCCA
GGGCGGGCCAGTGGCGGTGTTGAATCACAACCGTGTCATGGGCTACATGGTTCCGGCCGAGGTTTTCGAAGCGTTGATGG
AACGCCTGGATGATCTGGAGTTGGCCGAAATCGTTCGCGCGCGCAGCCATGAGACGCCCGTTCCGGTCAGTCTGGATGAC
TTATAG

Structures

Antitoxin

• AlphaFold DB: A0A0D6BA30