Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2586307..2586883 Replicon chromosome
Accession NZ_CP031393
Organism Treponema medium strain ATCC 700293

Toxin (Protein)


Gene name hicA Uniprot ID A0A898DH15
Locus tag DWB79_RS11340 Protein ID WP_040859254.1
Coordinates 2586307..2586495 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A898DF69
Locus tag DWB79_RS11345 Protein ID WP_016524185.1
Coordinates 2586500..2586883 (+) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DWB79_RS11320 2581530..2582111 + 582 WP_016524181.1 hypothetical protein -
DWB79_RS11325 2582251..2583381 + 1131 WP_206181007.1 glycosyltransferase -
DWB79_RS11330 2583408..2585061 - 1654 Protein_2207 nucleoside kinase -
DWB79_RS11340 2586307..2586495 + 189 WP_040859254.1 type II toxin-antitoxin system HicA family toxin Toxin
DWB79_RS11345 2586500..2586883 + 384 WP_016524185.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DWB79_RS11350 2587027..2588547 - 1521 WP_016524186.1 MiaB/RimO family radical SAM methylthiotransferase -
DWB79_RS11355 2588540..2589658 - 1119 WP_016524187.1 helix-turn-helix domain-containing protein -
DWB79_RS11360 2589696..2590382 - 687 WP_016524188.1 outer membrane lipoprotein carrier protein LolA -
DWB79_RS11365 2590680..2591216 - 537 WP_016524189.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-102)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7228.47 Da        Isoelectric Point: 10.4338

>T109170 WP_040859254.1 NZ_CP031393:2586307-2586495 [Treponema medium]
MNFKEMEKMIKQDGWVKRDIVGSHHHYEHPVKKGKVTIPFHGNKELSKFVVNSILKQAGLKE

Download         Length: 189 bp

>T109170 NZ_CP031393:2586307-2586495 [Treponema medium]
ATGAACTTTAAAGAAATGGAGAAGATGATAAAACAAGACGGATGGGTAAAACGTGATATAGTTGGGTCACATCATCACTA
TGAGCATCCGGTTAAAAAAGGGAAGGTTACTATTCCATTTCACGGTAATAAGGAGCTTTCAAAGTTTGTAGTAAATAGTA
TTCTTAAACAAGCAGGATTAAAGGAGTAA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 14285.40 Da        Isoelectric Point: 4.3514

>AT109170 WP_016524185.1 NZ_CP031393:2586500-2586883 [Treponema medium]
MYIYPAIFYKDENGYSVVFYDIELATMGDTLEEALIMAEEALTGRISLLLKDGETLPNPTAIEDIEKPKDAEFITLVKTD
RKYLAQEKSVRKNLTIPAWLAEAAENAGLNFSQELQCALKTRLHIGI

Download         Length: 384 bp

>AT109170 NZ_CP031393:2586500-2586883 [Treponema medium]
ATGTATATTTATCCGGCAATTTTTTATAAAGATGAAAACGGTTATTCGGTTGTATTTTATGATATAGAACTTGCAACGAT
GGGAGACACATTGGAAGAAGCGTTGATAATGGCAGAGGAAGCATTGACAGGACGTATCTCTTTACTTTTAAAGGATGGAG
AGACACTGCCCAATCCGACAGCTATAGAAGATATAGAAAAACCGAAAGATGCGGAATTTATTACACTGGTAAAAACCGAC
CGTAAATATCTGGCACAGGAAAAAAGTGTTCGTAAAAATTTAACAATTCCTGCCTGGCTTGCTGAAGCTGCCGAAAATGC
AGGATTAAATTTTTCGCAAGAGTTACAATGTGCTTTAAAAACGCGCTTGCATATTGGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References