Detailed information of TA system TA109169

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 1910891..1911456
• Replicon: chromosome
• Accession: NZ_CP031393
• Organism: Treponema medium strain ATCC 700293

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A898DFM3
• Locus tag: DWB79_RS08370
• Protein ID: WP_016523602.1
• Coordinates: 1910891..1911229 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A898DFU9
• Locus tag: DWB79_RS08375
• Protein ID: WP_016523603.1
• Coordinates: 1911223..1911456 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DWB79_RS08355	1906531..1907097	+	567	WP_016523599.1	redoxin domain-containing protein	-
DWB79_RS08360	1907308..1910118	-	2811	WP_016523600.1	hypothetical protein	-
DWB79_RS08365	1910329..1910553	-	225	WP_040859157.1	hypothetical protein	-
DWB79_RS08370	1910891..1911229	-	339	WP_016523602.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
DWB79_RS08375	1911223..1911456	-	234	WP_016523603.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
DWB79_RS08380	1911760..1913064	+	1305	WP_016523604.1	OmpA family protein	-
DWB79_RS08385	1913092..1913796	-	705	WP_040859594.1	ThiF family adenylyltransferase	-
DWB79_RS08390	1913867..1914925	-	1059	WP_016523606.1	phospho-N-acetylmuramoyl-pentapeptide- transferase	-
DWB79_RS08395	1915376..1915879	-	504	WP_016523607.1	crossover junction endodeoxyribonuclease RuvC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-110)

Antitoxin

• Antitoxin PemI-like (1-77)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12642.57 Da
• Isoelectric Point: 5.5485

>T109169 WP_016523602.1 NZ_CP031393:c1911229-1910891 [Treponema medium]
MVITGFIPEKGDLVWLEFNPQAGHEQQGHSPAMCVSQKLYNQKTGLALFCPITSHVKGYPFEVVLNDHSIKGCILSDQIK
NLDYVQRKCSFIEKASEDEINSVIDNIKLMME

Nucleotide

• Length: 339 bp

>T109169 NZ_CP031393:c1911229-1910891 [Treponema medium]
ATGGTAATTACCGGTTTTATTCCTGAAAAAGGAGATTTAGTTTGGTTAGAATTTAATCCGCAAGCAGGACATGAACAACA
GGGACATAGCCCTGCAATGTGTGTTTCTCAAAAATTATATAACCAAAAAACAGGATTGGCGTTATTTTGCCCGATTACAA
GTCACGTAAAAGGCTATCCATTTGAAGTCGTTTTAAATGACCATTCAATAAAAGGTTGTATTTTGAGTGATCAAATAAAA
AACTTGGATTATGTTCAAAGAAAATGCAGTTTTATAGAAAAAGCTTCAGAAGATGAAATAAATTCTGTAATAGATAATAT
AAAGCTGATGATGGAATAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8706.09 Da
• Isoelectric Point: 7.0128

>AT109169 WP_016523603.1 NZ_CP031393:c1911456-1911223 [Treponema medium]
MQAVVQKWGNSLGLRIPSLWAKDNNVKNGSKVEVIAEKGKMLILPQKKSLEDIMNLVTDENIHSEIKTFEAVGKEEW

Nucleotide

• Length: 234 bp

>AT109169 NZ_CP031393:c1911456-1911223 [Treponema medium]
ATGCAGGCAGTAGTTCAGAAATGGGGAAATAGTCTCGGGCTTAGAATTCCGTCACTTTGGGCAAAAGATAACAATGTTAA
AAATGGAAGCAAAGTAGAAGTAATTGCAGAAAAAGGGAAAATGCTCATTCTTCCTCAAAAAAAATCACTTGAAGATATTA
TGAATCTTGTTACGGATGAAAATATCCATTCAGAAATAAAAACTTTTGAAGCAGTAGGAAAAGAAGAATGGTAA