Detailed information of TA system TA109168

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 784043..784680
• Replicon: chromosome
• Accession: NZ_CP031393
• Organism: Treponema medium strain ATCC 700293

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DWB79_RS03505
• Protein ID: WP_016522664.1
• Coordinates: 784043..784450 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A898DEW2
• Locus tag: DWB79_RS03510
• Protein ID: WP_016522665.1
• Coordinates: 784450..784680 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DWB79_RS03495	780158..780613	-	456	Protein_676	PD-(D/E)XK nuclease family protein	-
DWB79_RS03500	780860..783766	-	2907	Protein_677	UvrD-helicase domain-containing protein	-
DWB79_RS03505	784043..784450	-	408	WP_016522664.1	type II toxin-antitoxin system VapC family toxin	Toxin
DWB79_RS03510	784450..784680	-	231	WP_016522665.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
DWB79_RS03515	784866..785927	-	1062	WP_016522666.1	hypothetical protein	-
DWB79_RS03520	785932..786183	-	252	WP_206181077.1	DUF1232 domain-containing protein	-
DWB79_RS03525	788056..788691	+	636	Protein_682	ISAs1 family transposase	-
DWB79_RS03530	788783..789286	+	504	Protein_683	ISAs1 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

• SpoVT-AbrB domain (7-46)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15682.04 Da
• Isoelectric Point: 6.9290

>T109168 WP_016522664.1 NZ_CP031393:c784450-784043 [Treponema medium]
MYLLDTNICIFLIKNKNPYLKKKIFNCKKEELFISSITIAELEYGVSKSQFREKNRHALLNFCSDFTNIIDFTTEDTETY
GMIRAYLENKGIPIGPFDTQIAAQSLARNLTVVTNNIREFSRIPGLKVEDWTKEE

Nucleotide

• Length: 408 bp

>T109168 NZ_CP031393:c784450-784043 [Treponema medium]
ATGTATTTGCTAGATACAAATATCTGTATTTTTCTTATAAAGAATAAAAATCCATATTTAAAGAAAAAAATATTTAACTG
TAAAAAAGAAGAATTATTTATTTCTTCCATTACAATTGCTGAGCTGGAGTATGGTGTTTCAAAAAGTCAATTTAGAGAAA
AGAATCGTCATGCTCTTTTGAATTTTTGTTCCGATTTTACTAACATAATAGATTTTACGACCGAAGATACAGAAACGTAC
GGAATGATTAGAGCATATCTTGAAAATAAAGGAATTCCGATTGGACCTTTTGATACGCAGATTGCCGCTCAAAGTTTAGC
AAGAAATCTTACTGTGGTTACAAATAATATAAGAGAATTTTCTAGAATTCCAGGACTAAAAGTCGAAGACTGGACAAAAG
AAGAATAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8761.91 Da
• Isoelectric Point: 4.7660

>AT109168 WP_016522665.1 NZ_CP031393:c784680-784450 [Treponema medium]
MVYAKVFTSGNSQAVRIPKEFHIDFSELCIKKIGSSIILTPKESNWENLERSLSEFSDDFMTEGRSQPAMQEREVF

Nucleotide

• Length: 231 bp

>AT109168 NZ_CP031393:c784680-784450 [Treponema medium]
ATGGTTTATGCAAAAGTATTCACAAGTGGAAATAGTCAGGCAGTAAGGATACCGAAAGAATTTCATATTGATTTTTCTGA
ATTATGCATCAAGAAAATCGGCTCATCAATAATCTTAACACCAAAAGAAAGCAATTGGGAAAATCTTGAAAGAAGTCTTT
CTGAGTTTTCTGATGATTTCATGACAGAAGGTAGAAGTCAACCGGCAATGCAAGAACGGGAAGTTTTTTAA