Detailed information of TA system TA109166

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3647441..3648094
• Replicon: chromosome
• Accession: NZ_CP031383
• Organism: Acinetobacter baumannii strain LUH 6011

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: DLE02_RS17460
• Protein ID: WP_000607077.1
• Coordinates: 3647441..3647830 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: DLE02_RS17465
• Protein ID: WP_001288210.1
• Coordinates: 3647837..3648094 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLE02_RS17445 (DLE02_03450)	3642559..3644754	-	2196	WP_001158906.1	TRAP transporter large permease subunit	-
DLE02_RS17450 (DLE02_03451)	3644942..3645508	-	567	WP_000651538.1	rhombosortase	-
DLE02_RS17455 (DLE02_03452)	3645586..3646671	-	1086	WP_000049106.1	hypothetical protein	-
DLE02_RS17460 (DLE02_03454)	3647441..3647830	-	390	WP_000607077.1	membrane protein	Toxin
DLE02_RS17465 (DLE02_03455)	3647837..3648094	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
DLE02_RS17470 (DLE02_03456)	3648282..3649454	+	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
DLE02_RS17475 (DLE02_03457)	3649503..3650993	-	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
DLE02_RS17480 (DLE02_03458)	3651175..3651552	-	378	WP_001216380.1	50S ribosomal protein L17	-
DLE02_RS17485 (DLE02_03459)	3651571..3652578	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T109166 WP_000607077.1 NZ_CP031383:c3647830-3647441 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T109166 NZ_CP031383:c3647830-3647441 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT109166 WP_001288210.1 NZ_CP031383:c3648094-3647837 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT109166 NZ_CP031383:c3648094-3647837 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7