Detailed information of TA system TA109165

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3077887..3078538
• Replicon: chromosome
• Accession: NZ_CP031383
• Organism: Acinetobacter baumannii strain LUH 6011

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: DLE02_RS14795
• Protein ID: WP_000838146.1
• Coordinates: 3078356..3078538 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0J1AAF8
• Locus tag: DLE02_RS14790
• Protein ID: WP_000966689.1
• Coordinates: 3077887..3078291 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLE02_RS14775 (DLE02_02919)	3072920..3073261	-	342	WP_001281459.1	phage tail protein	-
DLE02_RS14780 (DLE02_02920)	3073379..3077344	-	3966	WP_000191304.1	tape measure protein	-
DLE02_RS14785 (DLE02_02921)	3077405..3077806	-	402	WP_000720591.1	hypothetical protein	-
DLE02_RS14790 (DLE02_02922)	3077887..3078291	-	405	WP_000966689.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DLE02_RS14795 (DLE02_02923)	3078356..3078538	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
DLE02_RS14800 (DLE02_02924)	3078870..3079403	-	534	WP_001185622.1	hypothetical protein	-
DLE02_RS14805 (DLE02_02925)	3079448..3080377	-	930	WP_000094299.1	phage tail tube protein	-
DLE02_RS14810 (DLE02_02926)	3080485..3080697	-	213	WP_000121166.1	hypothetical protein	-
DLE02_RS14815 (DLE02_02927)	3080699..3081097	-	399	WP_001132270.1	hypothetical protein	-
DLE02_RS14820 (DLE02_02928)	3081099..3081467	-	369	WP_000539752.1	hypothetical protein	-
DLE02_RS14825 (DLE02_02929)	3081439..3081843	-	405	WP_000248323.1	hypothetical protein	-
DLE02_RS14830 (DLE02_02930)	3081852..3082220	-	369	WP_000524231.1	hypothetical protein	-
DLE02_RS14835 (DLE02_02931)	3082222..3082611	-	390	WP_000008492.1	hypothetical protein	-
DLE02_RS14840 (DLE02_02932)	3082616..3083281	-	666	WP_000767881.1	Ish1 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3053227..3119466	66239

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T109165 WP_000838146.1 NZ_CP031383:c3078538-3078356 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T109165 NZ_CP031383:c3078538-3078356 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14769.78 Da
• Isoelectric Point: 4.5000

>AT109165 WP_000966689.1 NZ_CP031383:c3078291-3077887 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT109165 NZ_CP031383:c3078291-3077887 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: A0A0J1AAF8