Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 7024..7549 Replicon plasmid pACICU1
Accession NZ_CP031381
Organism Acinetobacter baumannii ACICU

Toxin (Protein)


Gene name relE Uniprot ID A0A7U3Y3F8
Locus tag DMO12_RS18825 Protein ID WP_000221350.1
Coordinates 7262..7549 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R9B9T8
Locus tag DMO12_RS18820 Protein ID WP_000192612.1
Coordinates 7024..7272 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DMO12_RS18775 2297..3001 + 705 WP_001067856.1 IS6-like element IS26 family transposase -
DMO12_RS18785 3363..3557 - 195 Protein_5 hypothetical protein -
DMO12_RS18790 3552..3890 + 339 Protein_6 DUF3387 domain-containing protein -
DMO12_RS18795 4095..5042 - 948 WP_000845976.1 replication initiation protein RepM -
DMO12_RS18800 5467..6096 + 630 WP_000584713.1 AAA family ATPase -
DMO12_RS18805 6093..6329 + 237 WP_000592589.1 hypothetical protein -
DMO12_RS18810 6445..6513 + 69 Protein_10 helix-turn-helix domain-containing protein -
DMO12_RS18815 6596..7021 + 426 WP_001083446.1 hypothetical protein -
DMO12_RS18820 7024..7272 + 249 WP_000192612.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DMO12_RS18825 7262..7549 + 288 WP_000221350.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DMO12_RS18830 7821..9070 + 1250 Protein_14 IS3 family transposase -
DMO12_RS18835 9707..10273 + 567 WP_000678311.1 recombinase family protein -
DMO12_RS18840 10482..11000 - 519 WP_000447193.1 sel1 repeat family protein -
DMO12_RS18845 11251..11553 - 303 Protein_17 IS1-like element ISAba3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-58 - 1..24268 24268
- flank IS/Tn - - 2297..3001 704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11054.85 Da        Isoelectric Point: 10.0443

>T109163 WP_000221350.1 NZ_CP031381:7262-7549 [Acinetobacter baumannii ACICU]
MTYKLDFLEEALAEWNKLNPSIKQPLKKKLIKVLENPHIPKNKLSGHPNRYKIKLRSVGYRLVYEVIDDEVVVIVIAVGR
RENNAVYDEANSRHS

Download         Length: 288 bp

>T109163 NZ_CP031381:7262-7549 [Acinetobacter baumannii ACICU]
ATGACCTATAAGTTAGACTTTTTAGAAGAAGCATTAGCAGAATGGAATAAGCTTAATCCAAGTATTAAGCAACCATTGAA
GAAGAAACTGATCAAGGTACTAGAGAATCCTCACATTCCCAAGAATAAGCTCTCAGGACATCCTAACCGCTACAAGATCA
AACTTCGCAGTGTTGGTTATCGTTTGGTTTATGAAGTGATTGATGATGAGGTTGTTGTCATCGTCATTGCCGTAGGCAGA
CGTGAAAACAATGCTGTGTATGATGAAGCCAACTCTCGACATTCATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9246.72 Da        Isoelectric Point: 5.0491

>AT109163 WP_000192612.1 NZ_CP031381:7024-7272 [Acinetobacter baumannii ACICU]
MTQLIHARMTASITELKKSPMDTVLAGKGEPVAILNRNTPAFYCVPADLYETMMEQLEDLELNKIADARANQKRIRVNID
DL

Download         Length: 249 bp

>AT109163 NZ_CP031381:7024-7272 [Acinetobacter baumannii ACICU]
ATGACTCAATTAATCCATGCACGAATGACTGCAAGTATTACTGAACTCAAAAAGAGTCCGATGGATACAGTGTTAGCAGG
TAAAGGTGAACCTGTAGCGATCCTTAATCGTAATACACCAGCGTTTTACTGTGTTCCGGCTGATTTGTATGAAACCATGA
TGGAACAACTGGAAGACCTGGAACTCAACAAAATTGCAGATGCTCGTGCGAATCAAAAACGCATTCGAGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3Y3F8

Antitoxin

Source ID Structure
AlphaFold DB R9B9T8

References