Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2917163..2917814 Replicon chromosome
Accession NZ_CP031380
Organism Acinetobacter baumannii ACICU

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag DMO12_RS13965 Protein ID WP_000838146.1
Coordinates 2917632..2917814 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag DMO12_RS13960 Protein ID WP_000966689.1
Coordinates 2917163..2917567 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DMO12_RS13945 2912196..2912537 - 342 WP_001281459.1 phage tail protein -
DMO12_RS13950 2912655..2916620 - 3966 WP_000191304.1 tape measure protein -
DMO12_RS13955 2916681..2917082 - 402 WP_000720591.1 hypothetical protein -
DMO12_RS13960 2917163..2917567 - 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DMO12_RS13965 2917632..2917814 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
DMO12_RS13970 2918146..2918679 - 534 WP_001185622.1 hypothetical protein -
DMO12_RS13975 2918724..2919653 - 930 WP_000094299.1 hypothetical protein -
DMO12_RS13980 2919761..2919973 - 213 WP_000121166.1 hypothetical protein -
DMO12_RS13985 2919975..2920373 - 399 WP_001132270.1 hypothetical protein -
DMO12_RS13990 2920375..2920743 - 369 WP_000539752.1 hypothetical protein -
DMO12_RS13995 2920715..2921119 - 405 WP_000248323.1 hypothetical protein -
DMO12_RS14000 2921128..2921541 - 414 WP_001197735.1 hypothetical protein -
DMO12_RS14005 2921498..2921887 - 390 WP_000008492.1 hypothetical protein -
DMO12_RS14010 2921892..2922557 - 666 WP_000767881.1 stress-responsive nuclear envelope protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2892503..2948208 55705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T109161 WP_000838146.1 NZ_CP031380:c2917814-2917632 [Acinetobacter baumannii ACICU]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T109161 NZ_CP031380:c2917814-2917632 [Acinetobacter baumannii ACICU]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT109161 WP_000966689.1 NZ_CP031380:c2917567-2917163 [Acinetobacter baumannii ACICU]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT109161 NZ_CP031380:c2917567-2917163 [Acinetobacter baumannii ACICU]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References