109158

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-couple_hipB
Location 1063827..1065070 Replicon chromosome
Accession NZ_CP031379
Organism Streptococcus suis strain ISU2660

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag DK878_RS05330 Protein ID WP_180821244.1
Coordinates 1063827..1064594 (-) Length 256 a.a.

Antitoxin (Protein)


Gene name sezA Uniprot ID -
Locus tag DK878_RS05335 Protein ID WP_000578719.1
Coordinates 1064594..1065070 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK878_RS05315 1060221..1060586 - 366 WP_000431640.1 plasmid mobilization relaxosome protein MobC -
DK878_RS05320 1060589..1060951 - 363 WP_000140674.1 hypothetical protein -
DK878_RS05325 1061284..1063791 - 2508 WP_180821243.1 AAA family ATPase -
DK878_RS05330 1063827..1064594 - 768 WP_180821244.1 zeta toxin family protein Toxin
DK878_RS05335 1064594..1065070 - 477 WP_000578719.1 helix-turn-helix domain-containing protein Antitoxin
DK878_RS05340 1065140..1065430 - 291 WP_000667951.1 hypothetical protein -
DK878_RS05345 1065481..1065870 - 390 WP_000048066.1 hypothetical protein -
DK878_RS05350 1065867..1066094 - 228 WP_000110922.1 hypothetical protein -
DK878_RS05355 1066122..1067222 - 1101 WP_180821245.1 toprim domain-containing protein -
DK878_RS05360 1067262..1067900 - 639 WP_053861411.1 hypothetical protein -
DK878_RS05365 1068360..1068873 + 514 Protein_1012 IS200/IS605 family transposase -
DK878_RS05370 1069234..1069734 - 501 WP_053866130.1 hypothetical protein -
DK878_RS05375 1069718..1069930 - 213 WP_053866131.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1068533..1068814 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29028.76 Da        Isoelectric Point: 4.9931

>T109158 WP_180821244.1 NZ_CP031379:c1064594-1063827 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESEKLFDQIQIYQRDRTCIYDSETDEGSAAEVLQSCLFGEWSKVEEEMM
KESELQLNELLEKNK

Download         Length: 768 bp

>T109158 NZ_CP031379:c1064594-1063827 [Streptococcus suis]
ATGAGACTGGAAGAATTTAGTGAGGCTGAGTTTCAGAAGGCCTTGCAGCGAACCATTCGGGCCTTAACCCGAGGAAAGAC
GATTCCAGATCAACCGAAAGCTATCTTGCTTGGTGGACAAAGCGGAGCGGGTAAGACGACTATTCATCGTATCAAGCAAA
AGGAATTTCAAGGTAATATCATTATTATCGATGGTGACAGCTACCGTTCTCAGCATCCCAATTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGATAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACATCTGGTTGATGAACTTAGCAC
ACAAGGTTATCATTTGCTGATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGCTTCGA
AAGGATACCAAGTTTCTTTAGCTGTCATTGGTACCAAACCAGAGCTTTCTTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGCCATCGATCCGACTCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTTGAGAACTTGGTTGATAA
CCTAAGGGAGTTAGAAAGTGAGAAACTCTTTGACCAAATTCAAATCTATCAAAGAGATAGAACTTGTATCTATGATTCTG
AAACTGATGAAGGTTCCGCAGCAGAAGTTCTACAAAGCTGCCTTTTCGGAGAGTGGAGTAAGGTTGAGGAAGAGATGATG
AAAGAGAGTGAACTCCAACTTAATGAATTACTTGAGAAAAATAAATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18266.77 Da        Isoelectric Point: 4.6424

>AT109158 WP_000578719.1 NZ_CP031379:c1065070-1064594 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp

>AT109158 NZ_CP031379:c1065070-1064594 [Streptococcus suis]
ATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGGATTTC
ACGCAATAGCCTGAGTCGCTACGAAAATGGTACCAGCACTGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACACCTGTCGAAGATTACCATCTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCAAAGCTTTATAGATACCAGGATAGTCAAGATATTGTTTTTGATGATGA
ATCTAATCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATCAATACGAAAATTTACCTTGTCGCTACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGATGGTATAGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References