109156

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 821819..822302 Replicon chromosome
Accession NZ_CP031379
Organism Streptococcus suis strain ISU2660

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8BIZ7
Locus tag DK878_RS04210 Protein ID WP_009910443.1
Coordinates 822042..822302 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag DK878_RS04205 Protein ID WP_012775256.1
Coordinates 821819..822040 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK878_RS04175 817997..818437 + 441 WP_024409208.1 hypothetical protein -
DK878_RS04180 818507..819007 + 501 WP_024409209.1 hypothetical protein -
DK878_RS04185 819147..819533 + 387 WP_009910450.1 hypothetical protein -
DK878_RS04190 819717..819899 + 183 WP_009910449.1 type II toxin-antitoxin system HicA family toxin -
DK878_RS04195 819939..820391 + 453 WP_009910448.1 type II toxin-antitoxin system HicB family antitoxin -
DK878_RS04200 820503..820712 + 210 WP_009910447.1 hypothetical protein -
DK878_RS04205 821819..822040 + 222 WP_012775256.1 hypothetical protein Antitoxin
DK878_RS04210 822042..822302 + 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DK878_RS04215 822469..823110 + 642 WP_002935700.1 HAD family hydrolase -
DK878_RS04220 823143..823328 - 186 WP_002935693.1 hypothetical protein -
DK878_RS04225 823392..824396 - 1005 WP_009910438.1 lactonase family protein -
DK878_RS04230 824532..825698 + 1167 WP_002935690.1 AI-2E family transporter -
DK878_RS04235 825688..826917 + 1230 WP_009910437.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 812213..823328 11115


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10270.78 Da        Isoelectric Point: 9.6925

>T109156 WP_009910443.1 NZ_CP031379:822042-822302 [Streptococcus suis]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T109156 NZ_CP031379:822042-822302 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAATTCAGAGGTTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT109156 WP_012775256.1 NZ_CP031379:821819-822040 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT109156 NZ_CP031379:821819-822040 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8BIZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References