109155

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 819717..820391 Replicon chromosome
Accession NZ_CP031379
Organism Streptococcus suis strain ISU2660

Toxin (Protein)


Gene name hicA Uniprot ID A0A123U128
Locus tag DK878_RS04190 Protein ID WP_009910449.1
Coordinates 819717..819899 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7Y6VEQ2
Locus tag DK878_RS04195 Protein ID WP_009910448.1
Coordinates 819939..820391 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK878_RS04140 814795..814998 + 204 WP_024409202.1 hypothetical protein -
DK878_RS04145 814991..815194 + 204 WP_024409203.1 hypothetical protein -
DK878_RS04150 815205..815471 + 267 WP_024409204.1 hypothetical protein -
DK878_RS04155 815482..815640 + 159 WP_162841287.1 hypothetical protein -
DK878_RS04160 815645..815860 + 216 WP_024409205.1 hypothetical protein -
DK878_RS04165 815874..816668 + 795 WP_079269917.1 DnaD domain protein -
DK878_RS04170 816684..817529 + 846 WP_024409207.1 ATP-binding protein -
DK878_RS04175 817997..818437 + 441 WP_024409208.1 hypothetical protein -
DK878_RS04180 818507..819007 + 501 WP_024409209.1 hypothetical protein -
DK878_RS04185 819147..819533 + 387 WP_009910450.1 hypothetical protein -
DK878_RS04190 819717..819899 + 183 WP_009910449.1 type II toxin-antitoxin system HicA family toxin Toxin
DK878_RS04195 819939..820391 + 453 WP_009910448.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DK878_RS04200 820503..820712 + 210 WP_009910447.1 hypothetical protein -
DK878_RS04205 821819..822040 + 222 WP_012775256.1 hypothetical protein -
DK878_RS04210 822042..822302 + 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin -
DK878_RS04215 822469..823110 + 642 WP_002935700.1 HAD family hydrolase -
DK878_RS04220 823143..823328 - 186 WP_002935693.1 hypothetical protein -
DK878_RS04225 823392..824396 - 1005 WP_009910438.1 lactonase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 812213..823328 11115


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6681.93 Da        Isoelectric Point: 10.8207

>T109155 WP_009910449.1 NZ_CP031379:819717-819899 [Streptococcus suis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKVGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

>T109155 NZ_CP031379:819717-819899 [Streptococcus suis]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACTAAAGGTGGTAAGGGGTCTCA
CGTTAAACTTGAAAAAGTAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16672.68 Da        Isoelectric Point: 4.0098

>AT109155 WP_009910448.1 NZ_CP031379:819939-820391 [Streptococcus suis]
MLVTYPALFYYDDTDGATAPYFVTFPDFEHSATQGEDMADAMAMASDWLGIHLADYIENGRDIPTPTPINALSLADNNPF
RDDKDIELVYDPSKSFVSMVMVDVAEYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 453 bp

>AT109155 NZ_CP031379:819939-820391 [Streptococcus suis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGACGATACAGACGGAGCTACCGCCCCTTATTTTGTCACTTTCCCAGA
CTTTGAACATTCAGCAACTCAGGGCGAAGATATGGCAGACGCTATGGCAATGGCTAGTGATTGGTTAGGTATTCATCTAG
CTGATTATATTGAGAATGGGCGTGATATTCCCACTCCTACCCCTATTAACGCTTTATCATTGGCTGATAATAACCCTTTC
CGTGATGATAAGGACATAGAGCTAGTTTATGACCCTAGCAAGTCTTTTGTATCTATGGTTATGGTTGACGTTGCTGAGTA
TCTAGGCAGTCAAGAGCCTGTAAAGAAAACACTAACTATTCCACGTTGGGCGGATACTTTAGGGCGTGAGTTAGGGCTAA
ATTTCTCACAGACCTTAACAGACGCTATTGCAGATAAGAAAATTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A123U128

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y6VEQ2

References