109154

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 490751..491237 Replicon chromosome
Accession NZ_CP031379
Organism Streptococcus suis strain ISU2660

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag DK878_RS02575 Protein ID WP_011922754.1
Coordinates 490968..491237 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag DK878_RS02570 Protein ID WP_002938604.1
Coordinates 490751..490978 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK878_RS02545 486083..486628 - 546 WP_009909618.1 NAD(P)H-dependent oxidoreductase -
DK878_RS02550 486691..487140 - 450 WP_009909619.1 MarR family transcriptional regulator -
DK878_RS02555 487443..487940 + 498 WP_002938611.1 DUF5590 domain-containing protein -
DK878_RS02560 487937..489118 + 1182 WP_002938610.1 pyridoxal phosphate-dependent aminotransferase -
DK878_RS02565 489133..490479 + 1347 WP_013730302.1 asparagine--tRNA ligase -
DK878_RS02570 490751..490978 + 228 WP_002938604.1 hypothetical protein Antitoxin
DK878_RS02575 490968..491237 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DK878_RS02580 491643..492962 + 1320 WP_002937278.1 MATE family efflux transporter -
DK878_RS02585 493146..493523 + 378 WP_013730303.1 RidA family protein -
DK878_RS02590 493545..494432 + 888 WP_002937261.1 RNase adapter RapZ -
DK878_RS02595 494429..495403 + 975 WP_002937257.1 YvcK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T109154 WP_011922754.1 NZ_CP031379:490968-491237 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T109154 NZ_CP031379:490968-491237 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT109154 WP_002938604.1 NZ_CP031379:490751-490978 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT109154 NZ_CP031379:490751-490978 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References