Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1687442..1687928 Replicon chromosome
Accession NZ_CP031377
Organism Streptococcus suis strain ISU2614

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag DK237_RS08475 Protein ID WP_011922754.1
Coordinates 1687442..1687711 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag DK237_RS08480 Protein ID WP_002938604.1
Coordinates 1687701..1687928 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK237_RS08455 1683276..1684250 - 975 WP_002937257.1 YvcK family protein -
DK237_RS08460 1684247..1685134 - 888 WP_002937261.1 RNase adapter RapZ -
DK237_RS08465 1685156..1685533 - 378 WP_013730303.1 RidA family protein -
DK237_RS08470 1685717..1687036 - 1320 WP_002937278.1 MATE family efflux transporter -
DK237_RS08475 1687442..1687711 - 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DK237_RS08480 1687701..1687928 - 228 WP_002938604.1 hypothetical protein Antitoxin
DK237_RS08485 1688200..1689546 - 1347 WP_013730302.1 asparagine--tRNA ligase -
DK237_RS08490 1689561..1690742 - 1182 WP_002938610.1 pyridoxal phosphate-dependent aminotransferase -
DK237_RS08495 1690739..1691236 - 498 WP_002938611.1 DUF5590 domain-containing protein -
DK237_RS08500 1691539..1691988 + 450 WP_009909619.1 MarR family transcriptional regulator -
DK237_RS08505 1692051..1692596 + 546 WP_009909618.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T109152 WP_011922754.1 NZ_CP031377:c1687711-1687442 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T109152 NZ_CP031377:c1687711-1687442 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT109152 WP_002938604.1 NZ_CP031377:c1687928-1687701 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT109152 NZ_CP031377:c1687928-1687701 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References