Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1360917..1361591 Replicon chromosome
Accession NZ_CP031377
Organism Streptococcus suis strain ISU2614

Toxin (Protein)


Gene name hicA Uniprot ID A0A123U128
Locus tag DK237_RS06870 Protein ID WP_009910449.1
Coordinates 1361409..1361591 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7Y6VEQ2
Locus tag DK237_RS06865 Protein ID WP_009910448.1
Coordinates 1360917..1361369 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK237_RS06835 1356912..1357916 + 1005 WP_009910438.1 lactonase family protein -
DK237_RS06840 1357980..1358165 + 186 WP_002935693.1 hypothetical protein -
DK237_RS06845 1358198..1358839 - 642 WP_002935700.1 HAD family hydrolase -
DK237_RS06850 1359006..1359266 - 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin -
DK237_RS06855 1359268..1359489 - 222 WP_012775256.1 hypothetical protein -
DK237_RS06860 1360596..1360805 - 210 WP_009910447.1 hypothetical protein -
DK237_RS06865 1360917..1361369 - 453 WP_009910448.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DK237_RS06870 1361409..1361591 - 183 WP_009910449.1 type II toxin-antitoxin system HicA family toxin Toxin
DK237_RS06875 1361775..1362161 - 387 WP_009910450.1 hypothetical protein -
DK237_RS06880 1362301..1362801 - 501 WP_024409209.1 hypothetical protein -
DK237_RS06885 1362871..1363311 - 441 WP_024409208.1 hypothetical protein -
DK237_RS06890 1363779..1364624 - 846 WP_024409207.1 ATP-binding protein -
DK237_RS06895 1364640..1365434 - 795 WP_079269917.1 DnaD domain protein -
DK237_RS06900 1365448..1365663 - 216 WP_024409205.1 hypothetical protein -
DK237_RS06905 1365668..1365826 - 159 WP_162841287.1 hypothetical protein -
DK237_RS06910 1365837..1366103 - 267 WP_024409204.1 hypothetical protein -
DK237_RS06915 1366114..1366317 - 204 WP_024409203.1 hypothetical protein -
DK237_RS06920 1366310..1366513 - 204 WP_024409202.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1357980..1369095 11115


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6681.93 Da        Isoelectric Point: 10.8207

>T109151 WP_009910449.1 NZ_CP031377:c1361591-1361409 [Streptococcus suis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKVGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

>T109151 NZ_CP031377:c1361591-1361409 [Streptococcus suis]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACTAAAGGTGGTAAGGGGTCTCA
CGTTAAACTTGAAAAAGTAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16672.68 Da        Isoelectric Point: 4.0098

>AT109151 WP_009910448.1 NZ_CP031377:c1361369-1360917 [Streptococcus suis]
MLVTYPALFYYDDTDGATAPYFVTFPDFEHSATQGEDMADAMAMASDWLGIHLADYIENGRDIPTPTPINALSLADNNPF
RDDKDIELVYDPSKSFVSMVMVDVAEYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 453 bp

>AT109151 NZ_CP031377:c1361369-1360917 [Streptococcus suis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGACGATACAGACGGAGCTACCGCCCCTTATTTTGTCACTTTCCCAGA
CTTTGAACATTCAGCAACTCAGGGCGAAGATATGGCAGACGCTATGGCAATGGCTAGTGATTGGTTAGGTATTCATCTAG
CTGATTATATTGAGAATGGGCGTGATATTCCCACTCCTACCCCTATTAACGCTTTATCATTGGCTGATAATAACCCTTTC
CGTGATGATAAGGACATAGAGCTAGTTTATGACCCTAGCAAGTCTTTTGTATCTATGGTTATGGTTGACGTTGCTGAGTA
TCTAGGCAGTCAAGAGCCTGTAAAGAAAACACTAACTATTCCACGTTGGGCGGATACTTTAGGGCGTGAGTTAGGGCTAA
ATTTCTCACAGACCTTAACAGACGCTATTGCAGATAAGAAAATTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A123U128

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y6VEQ2

References