Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1359006..1359489 Replicon chromosome
Accession NZ_CP031377
Organism Streptococcus suis strain ISU2614

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8BIZ7
Locus tag DK237_RS06850 Protein ID WP_009910443.1
Coordinates 1359006..1359266 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag DK237_RS06855 Protein ID WP_012775256.1
Coordinates 1359268..1359489 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK237_RS06825 1354391..1355620 - 1230 WP_009910437.1 tetratricopeptide repeat protein -
DK237_RS06830 1355610..1356776 - 1167 WP_002935690.1 AI-2E family transporter -
DK237_RS06835 1356912..1357916 + 1005 WP_009910438.1 lactonase family protein -
DK237_RS06840 1357980..1358165 + 186 WP_002935693.1 hypothetical protein -
DK237_RS06845 1358198..1358839 - 642 WP_002935700.1 HAD family hydrolase -
DK237_RS06850 1359006..1359266 - 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DK237_RS06855 1359268..1359489 - 222 WP_012775256.1 hypothetical protein Antitoxin
DK237_RS06860 1360596..1360805 - 210 WP_009910447.1 hypothetical protein -
DK237_RS06865 1360917..1361369 - 453 WP_009910448.1 type II toxin-antitoxin system HicB family antitoxin -
DK237_RS06870 1361409..1361591 - 183 WP_009910449.1 type II toxin-antitoxin system HicA family toxin -
DK237_RS06875 1361775..1362161 - 387 WP_009910450.1 hypothetical protein -
DK237_RS06880 1362301..1362801 - 501 WP_024409209.1 hypothetical protein -
DK237_RS06885 1362871..1363311 - 441 WP_024409208.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1357980..1369095 11115


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10270.78 Da        Isoelectric Point: 9.6925

>T109150 WP_009910443.1 NZ_CP031377:c1359266-1359006 [Streptococcus suis]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T109150 NZ_CP031377:c1359266-1359006 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAATTCAGAGGTTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT109150 WP_012775256.1 NZ_CP031377:c1359489-1359268 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT109150 NZ_CP031377:c1359489-1359268 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8BIZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References