Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 947174..947660 Replicon chromosome
Accession NZ_CP031377
Organism Streptococcus suis strain ISU2614

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2E5U8
Locus tag DK237_RS04855 Protein ID WP_002935012.1
Coordinates 947174..947431 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K2E5B0
Locus tag DK237_RS04860 Protein ID WP_002935014.1
Coordinates 947421..947660 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK237_RS04835 942808..943878 + 1071 WP_002935006.1 tyrosine recombinase XerS -
DK237_RS04840 943948..945456 - 1509 WP_013730362.1 phosphoglucomutase -
DK237_RS04845 945532..946473 - 942 WP_053861443.1 sensor histidine kinase -
DK237_RS04850 946470..947135 - 666 WP_009909826.1 response regulator transcription factor -
DK237_RS04855 947174..947431 - 258 WP_002935012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DK237_RS04860 947421..947660 - 240 WP_002935014.1 hypothetical protein Antitoxin
DK237_RS04865 947752..949722 - 1971 WP_013730363.1 FtsX-like permease family protein -
DK237_RS04870 949723..950475 - 753 WP_002935019.1 ABC transporter ATP-binding protein -
DK237_RS04875 950492..950875 - 384 WP_002935021.1 NisI/SpaI family lantibiotic immunity lipoprotein -
DK237_RS04880 950888..951028 - 141 WP_002935023.1 hypothetical protein -
DK237_RS04885 951127..951861 - 735 WP_002935025.1 beta-carotene 15,15'-monooxygenase -
DK237_RS04890 951874..952011 - 138 WP_002935027.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9849.52 Da        Isoelectric Point: 10.7134

>T109147 WP_002935012.1 NZ_CP031377:c947431-947174 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T109147 NZ_CP031377:c947431-947174 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.19 Da        Isoelectric Point: 3.9191

>AT109147 WP_002935014.1 NZ_CP031377:c947660-947421 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Download         Length: 240 bp

>AT109147 NZ_CP031377:c947660-947421 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATGACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E5U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E5B0

References