Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 177817..178342 Replicon plasmid p3
Accession NZ_CP031362
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain 5

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag DXF95_RS24815 Protein ID WP_001159871.1
Coordinates 177817..178122 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag DXF95_RS24820 Protein ID WP_000813630.1
Coordinates 178124..178342 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXF95_RS24785 173235..173932 - 698 Protein_178 IS1 family transposase -
DXF95_RS24790 173988..174404 - 417 WP_001278818.1 plasmid partitioning/stability family protein -
DXF95_RS24795 174397..175377 - 981 WP_000688514.1 plasmid segregation protein ParM -
DXF95_RS24800 175791..176099 - 309 WP_000030199.1 hypothetical protein -
DXF95_RS24805 176186..176830 - 645 WP_001144036.1 ParA family protein -
DXF95_RS24810 177010..177816 - 807 WP_000016969.1 site-specific integrase -
DXF95_RS24815 177817..178122 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
DXF95_RS24820 178124..178342 - 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
DXF95_RS24830 178900..179826 + 927 WP_001290416.1 hypothetical protein -
DXF95_RS24835 179871..180125 + 255 WP_000678527.1 hypothetical protein -
DXF95_RS24840 180624..180968 + 345 WP_000793307.1 hypothetical protein -
DXF95_RS24845 181144..182145 - 1002 WP_000774875.1 DUF4238 domain-containing protein -
DXF95_RS24850 182497..182751 + 255 WP_000343103.1 hypothetical protein -
DXF95_RS24855 182751..183341 + 591 WP_000194550.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..190543 190543


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T109146 WP_001159871.1 NZ_CP031362:c178122-177817 [Salmonella enterica subsp. enterica serovar Heidelberg]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T109146 NZ_CP031362:c178122-177817 [Salmonella enterica subsp. enterica serovar Heidelberg]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT109146 WP_000813630.1 NZ_CP031362:c178342-178124 [Salmonella enterica subsp. enterica serovar Heidelberg]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT109146 NZ_CP031362:c178342-178124 [Salmonella enterica subsp. enterica serovar Heidelberg]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References