Detailed information of TA system TA109144

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 27971..28493
• Replicon: plasmid p2
• Accession: NZ_CP031361
• Organism: Salmonella enterica subsp. enterica serovar Heidelberg strain 5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G3CAN5
• Locus tag: DXF95_RS23760
• Protein ID: WP_000220560.1
• Coordinates: 28212..28493 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: DXF95_RS23755
• Protein ID: WP_000121743.1
• Coordinates: 27971..28222 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXF95_RS23725	23642..23923	+	282	WP_001185482.1	hypothetical protein	-
DXF95_RS23730	23948..24925	+	978	WP_001269910.1	hypothetical protein	-
DXF95_RS23735	24922..25347	-	426	WP_000202944.1	hypothetical protein	-
DXF95_RS23740	25415..25861	-	447	WP_001074386.1	hypothetical protein	-
DXF95_RS23745	25901..26737	-	837	WP_001050931.1	replication initiation protein	-
DXF95_RS23755	27971..28222	+	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
DXF95_RS23760	28212..28493	+	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DXF95_RS23765	28639..28962	+	324	WP_001181903.1	hypothetical protein	-
DXF95_RS23770	29007..29252	+	246	WP_000356547.1	hypothetical protein	-
DXF95_RS23775	29242..29457	+	216	WP_001180116.1	hypothetical protein	-
DXF95_RS23780	29550..29879	+	330	WP_000866646.1	hypothetical protein	-
DXF95_RS23785	29922..30101	+	180	WP_000439078.1	hypothetical protein	-
DXF95_RS23790	30171..30320	+	150	WP_000003880.1	hypothetical protein	-
DXF95_RS23795	30333..30605	+	273	WP_000160399.1	hypothetical protein	-
DXF95_RS25155	30862..30936	+	75	Protein_37	DNA distortion polypeptide 3	-
DXF95_RS23800	30931..31476	+	546	WP_000757693.1	hypothetical protein	-
DXF95_RS23805	31479..32645	+	1167	WP_000539532.1	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..37697	37697

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-126)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 12066.38 Da
• Isoelectric Point: 12.7685

>T109144 WP_000220560.1 NZ_CP031361:28212-28493 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Nucleotide

• Length: 282 bp

>T109144 NZ_CP031361:28212-28493 [Salmonella enterica subsp. enterica serovar Heidelberg]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT109144 WP_000121743.1 NZ_CP031361:27971-28222 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Nucleotide

• Length: 252 bp

>AT109144 NZ_CP031361:27971-28222 [Salmonella enterica subsp. enterica serovar Heidelberg]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: G3CAN5

Antitoxin

• AlphaFold DB: A0A3S5I301