Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 27971..28493 Replicon plasmid p2
Accession NZ_CP031361
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain 5

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag DXF95_RS23760 Protein ID WP_000220560.1
Coordinates 28212..28493 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag DXF95_RS23755 Protein ID WP_000121743.1
Coordinates 27971..28222 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXF95_RS23725 23642..23923 + 282 WP_001185482.1 hypothetical protein -
DXF95_RS23730 23948..24925 + 978 WP_001269910.1 hypothetical protein -
DXF95_RS23735 24922..25347 - 426 WP_000202944.1 hypothetical protein -
DXF95_RS23740 25415..25861 - 447 WP_001074386.1 hypothetical protein -
DXF95_RS23745 25901..26737 - 837 WP_001050931.1 replication initiation protein -
DXF95_RS23755 27971..28222 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
DXF95_RS23760 28212..28493 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DXF95_RS23765 28639..28962 + 324 WP_001181903.1 hypothetical protein -
DXF95_RS23770 29007..29252 + 246 WP_000356547.1 hypothetical protein -
DXF95_RS23775 29242..29457 + 216 WP_001180116.1 hypothetical protein -
DXF95_RS23780 29550..29879 + 330 WP_000866646.1 hypothetical protein -
DXF95_RS23785 29922..30101 + 180 WP_000439078.1 hypothetical protein -
DXF95_RS23790 30171..30320 + 150 WP_000003880.1 hypothetical protein -
DXF95_RS23795 30333..30605 + 273 WP_000160399.1 hypothetical protein -
DXF95_RS25155 30862..30936 + 75 Protein_37 DNA distortion polypeptide 3 -
DXF95_RS23800 30931..31476 + 546 WP_000757693.1 hypothetical protein -
DXF95_RS23805 31479..32645 + 1167 WP_000539532.1 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..37697 37697


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-126)

Antitoxin

(2-38)


Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T109144 WP_000220560.1 NZ_CP031361:28212-28493 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T109144 NZ_CP031361:28212-28493 [Salmonella enterica subsp. enterica serovar Heidelberg]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 10784.64 Da        Isoelectric Point: 12.7191

>AT109144 WP_000121743.1 NZ_CP031361:27971-28222 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Download         Length: 252 bp

>AT109144 NZ_CP031361:27971-28222 [Salmonella enterica subsp. enterica serovar Heidelberg]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G3CAN5


Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References