Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1289029..1289824 Replicon chromosome
Accession NZ_CP031353
Organism Escherichia coli O145 strain RM9154-C1

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag DXE50_RS08100 Protein ID WP_000854914.1
Coordinates 1289450..1289824 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9LM11
Locus tag DXE50_RS08095 Protein ID WP_001280953.1
Coordinates 1289029..1289403 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE50_RS08065 1284384..1285289 + 906 WP_000203541.1 chemotaxis protein -
DXE50_RS08070 1285286..1286356 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
DXE50_RS08075 1286696..1287514 + 819 WP_001234682.1 DUF945 domain-containing protein -
DXE50_RS08080 1287605..1288090 + 486 WP_000214398.1 antirestriction protein -
DXE50_RS08085 1288106..1288582 + 477 WP_001186738.1 RadC family protein -
DXE50_RS08090 1288645..1288866 + 222 WP_000692323.1 DUF987 domain-containing protein -
DXE50_RS08095 1289029..1289403 + 375 WP_001280953.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DXE50_RS08100 1289450..1289824 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
DXE50_RS08105 1289821..1290312 + 492 WP_000976857.1 hypothetical protein -
DXE50_RS08110 1290324..1290521 + 198 WP_000839282.1 DUF957 domain-containing protein -
DXE50_RS08115 1290606..1291448 + 843 WP_001280481.1 DUF4942 domain-containing protein -
DXE50_RS08125 1291919..1292857 + 939 WP_000351301.1 glyoxylate/hydroxypyruvate reductase GhrA -
DXE50_RS08130 1292912..1293649 + 738 WP_000283664.1 zinc-binding phosphatase -
DXE50_RS08135 1293673..1294227 + 555 WP_001001917.1 molecular chaperone YcdY -
DXE50_RS08140 1294329..1294820 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T109086 WP_000854914.1 NZ_CP031353:1289450-1289824 [Escherichia coli O145]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T109086 NZ_CP031353:1289450-1289824 [Escherichia coli O145]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13734.56 Da        Isoelectric Point: 6.6249

>AT109086 WP_001280953.1 NZ_CP031353:1289029-1289403 [Escherichia coli O145]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS

Download         Length: 375 bp

>AT109086 NZ_CP031353:1289029-1289403 [Escherichia coli O145]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACTCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LM11

References