Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 5179772..5180367 Replicon chromosome
Accession NZ_CP031341
Organism Escherichia coli O145 strain RM12275-C1

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag DXE55_RS26075 Protein ID WP_000239579.1
Coordinates 5180017..5180367 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag DXE55_RS26070 Protein ID WP_001223208.1
Coordinates 5179772..5180023 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE55_RS26060 5175437..5179216 + 3780 WP_000060846.1 autotransporter assembly complex protein TamB -
DXE55_RS26065 5179219..5179560 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
DXE55_RS26070 5179772..5180023 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
DXE55_RS26075 5180017..5180367 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
DXE55_RS26080 5180447..5180977 - 531 WP_000055075.1 inorganic diphosphatase -
DXE55_RS26085 5181287..5182243 + 957 WP_000265940.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
DXE55_RS26090 5182383..5183885 + 1503 WP_000205816.1 sugar ABC transporter ATP-binding protein -
DXE55_RS26095 5183899..5184921 + 1023 WP_001400707.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T108965 WP_000239579.1 NZ_CP031341:5180017-5180367 [Escherichia coli O145]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T108965 NZ_CP031341:5180017-5180367 [Escherichia coli O145]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT108965 WP_001223208.1 NZ_CP031341:5179772-5180023 [Escherichia coli O145]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT108965 NZ_CP031341:5179772-5180023 [Escherichia coli O145]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References