Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1348554..1349349 Replicon chromosome
Accession NZ_CP031341
Organism Escherichia coli O145 strain RM12275-C1

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag DXE55_RS06935 Protein ID WP_000854914.1
Coordinates 1348975..1349349 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9LM11
Locus tag DXE55_RS06930 Protein ID WP_001280953.1
Coordinates 1348554..1348928 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXE55_RS06900 1343909..1344814 + 906 WP_000203541.1 chemotaxis protein -
DXE55_RS06905 1344811..1345881 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
DXE55_RS06910 1346221..1347039 + 819 WP_001234682.1 DUF945 domain-containing protein -
DXE55_RS06915 1347130..1347615 + 486 WP_000214398.1 antirestriction protein -
DXE55_RS06920 1347631..1348107 + 477 WP_001186738.1 RadC family protein -
DXE55_RS06925 1348170..1348391 + 222 WP_000692323.1 DUF987 domain-containing protein -
DXE55_RS06930 1348554..1348928 + 375 WP_001280953.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DXE55_RS06935 1348975..1349349 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
DXE55_RS06940 1349346..1349837 + 492 WP_000976857.1 hypothetical protein -
DXE55_RS06945 1349849..1350046 + 198 WP_000839282.1 DUF957 domain-containing protein -
DXE55_RS06950 1350131..1350973 + 843 WP_001280481.1 DUF4942 domain-containing protein -
DXE55_RS06960 1351444..1352382 + 939 WP_000351301.1 glyoxylate/hydroxypyruvate reductase GhrA -
DXE55_RS06965 1352437..1353174 + 738 WP_000283664.1 zinc-binding phosphatase -
DXE55_RS06970 1353198..1353752 + 555 WP_001001917.1 molecular chaperone YcdY -
DXE55_RS06975 1353854..1354345 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1347631..1359282 11651


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T108940 WP_000854914.1 NZ_CP031341:1348975-1349349 [Escherichia coli O145]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T108940 NZ_CP031341:1348975-1349349 [Escherichia coli O145]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13734.56 Da        Isoelectric Point: 6.6249

>AT108940 WP_001280953.1 NZ_CP031341:1348554-1348928 [Escherichia coli O145]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS

Download         Length: 375 bp

>AT108940 NZ_CP031341:1348554-1348928 [Escherichia coli O145]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACTCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LM11

References