Detailed information of TA system TA108900

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 4273030..4273502
• Replicon: chromosome
• Accession: NZ_CP031316
• Organism: Serratia marcescens strain N4-5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5C7D428
• Locus tag: Smn45_RS20570
• Protein ID: WP_049208401.1
• Coordinates: 4273030..4273305 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8G2LC23
• Locus tag: Smn45_RS20575
• Protein ID: WP_016930068.1
• Coordinates: 4273311..4273502 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Smn45_RS20545	4268349..4269629	-	1281	WP_115436511.1	polysaccharide deacetylase family protein	-
Smn45_RS20550	4269807..4270577	-	771	WP_004937535.1	ABC transporter permease	-
Smn45_RS20555	4270574..4271497	-	924	WP_015379030.1	ABC transporter ATP-binding protein	-
Smn45_RS20560	4271708..4272364	+	657	WP_016930066.1	carbonate dehydratase	-
Smn45_RS20565	4272403..4272939	-	537	WP_004937527.1	hypoxanthine phosphoribosyltransferase	-
Smn45_RS20570	4273030..4273305	-	276	WP_049208401.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Smn45_RS20575	4273311..4273502	-	192	WP_016930068.1	hypothetical protein	Antitoxin
Smn45_RS20580	4273608..4275251	-	1644	WP_115436512.1	multicopper oxidase CueO	-
Smn45_RS20585	4275468..4275815	+	348	WP_033634347.1	YacC family pilotin-like protein	-
Smn45_RS20590	4275941..4276804	+	864	WP_016930071.1	polyamine aminopropyltransferase	-
Smn45_RS20595	4276832..4277626	+	795	WP_004937510.1	adenosylmethionine decarboxylase	-
Smn45_RS20600	4277659..4278021	-	363	WP_016930072.1	protein YacL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10410.13 Da
• Isoelectric Point: 6.8785

>T108900 WP_049208401.1 NZ_CP031316:c4273305-4273030 [Serratia marcescens]
MLTVKWTDEAKTGLYTLLAFIAERNPLAAEALLQRIEESVIPLAEHPYLFRPGRVNGTREMVVHPNYIVVYRVLAAHIEI
VSVLHARQEYP

Nucleotide

• Length: 276 bp

>T108900 NZ_CP031316:c4273305-4273030 [Serratia marcescens]
ATGTTAACCGTCAAATGGACTGACGAAGCAAAAACGGGTTTATATACGCTGCTGGCTTTTATCGCTGAGCGAAATCCACT
TGCCGCTGAGGCGTTGTTACAACGCATTGAAGAGTCGGTTATCCCGTTAGCGGAACATCCTTATCTATTCCGGCCAGGCA
GGGTGAACGGGACTCGTGAAATGGTTGTTCATCCTAATTACATTGTGGTTTACCGCGTGCTGGCTGCACATATTGAAATA
GTGAGTGTCCTGCACGCTCGTCAGGAATACCCTTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7178.94 Da
• Isoelectric Point: 5.6492

>AT108900 WP_016930068.1 NZ_CP031316:c4273502-4273311 [Serratia marcescens]
MPTKLDPIVSEFETQEQADSYDRWFRSTVESSINSDSSRIPHDEVMAGARHIIEQAKAKRKSA

Nucleotide

• Length: 192 bp

>AT108900 NZ_CP031316:c4273502-4273311 [Serratia marcescens]
ATGCCGACAAAATTGGATCCCATCGTTTCTGAGTTTGAGACTCAAGAGCAGGCTGATAGCTACGATCGTTGGTTCAGAAG
CACCGTGGAATCTTCCATCAATAGCGACTCCTCCCGTATCCCCCATGACGAAGTCATGGCCGGCGCTCGTCACATTATCG
AGCAGGCGAAAGCCAAAAGAAAATCGGCCTGA

Structures

Toxin

• AlphaFold DB: A0A5C7D428