Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3792979..3793635 Replicon chromosome
Accession NZ_CP031316
Organism Serratia marcescens strain N4-5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag Smn45_RS18310 Protein ID WP_016926704.1
Coordinates 3792979..3793368 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag Smn45_RS18315 Protein ID WP_004941563.1
Coordinates 3793372..3793635 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Smn45_RS18295 3789447..3790877 + 1431 WP_162807763.1 multidrug transporter subunit MdtD -
Smn45_RS18300 3790874..3792256 + 1383 WP_016926705.1 two-component system sensor histidine kinase BaeS -
Smn45_RS18305 3792256..3792972 + 717 WP_004941568.1 two-component system response regulator BaeR -
Smn45_RS18310 3792979..3793368 - 390 WP_016926704.1 type II toxin-antitoxin system VapC family toxin Toxin
Smn45_RS18315 3793372..3793635 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Smn45_RS18320 3793974..3794312 + 339 WP_016926703.1 YegP family protein -
Smn45_RS18325 3794491..3795843 + 1353 WP_115436397.1 tRNA 5-hydroxyuridine modification protein YegQ -
Smn45_RS18330 3796311..3797216 + 906 WP_016926701.1 lipid kinase YegS -
Smn45_RS18335 3797383..3798597 + 1215 WP_115436398.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14342.61 Da        Isoelectric Point: 7.8794

>T108898 WP_016926704.1 NZ_CP031316:c3793368-3792979 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RATMERKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T108898 NZ_CP031316:c3793368-3792979 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCAGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGTTGCTACGGTGAAATG
CGGGCAACCATGGAGAGAAAGGGCAAAATCATGGGCGCGATGGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT108898 WP_004941563.1 NZ_CP031316:c3793635-3793372 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT108898 NZ_CP031316:c3793635-3793372 [Serratia marcescens]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAATTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTGGCAGACCGC
GATCCGTTCTCAGAGGAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References