Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3708052..3708614 Replicon chromosome
Accession NZ_CP031316
Organism Serratia marcescens strain N4-5

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag Smn45_RS17910 Protein ID WP_025303801.1
Coordinates 3708052..3708408 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag Smn45_RS17915 Protein ID WP_004936539.1
Coordinates 3708405..3708614 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Smn45_RS17890 3703788..3704585 - 798 WP_115436375.1 energy transducer TonB -
Smn45_RS17895 3704688..3705527 - 840 WP_115436376.1 ChaN family lipoprotein -
Smn45_RS17900 3705705..3707114 + 1410 WP_033639696.1 S-methylmethionine permease -
Smn45_RS17905 3707104..3708042 + 939 WP_115436377.1 homocysteine S-methyltransferase -
Smn45_RS17910 3708052..3708408 - 357 WP_025303801.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
Smn45_RS17915 3708405..3708614 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Smn45_RS17920 3708724..3711003 - 2280 WP_016926766.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
Smn45_RS17925 3711372..3711755 - 384 WP_049299550.1 DUF2570 family protein -
Smn45_RS17930 3711752..3712153 - 402 WP_033639692.1 M15 family metallopeptidase -
Smn45_RS17935 3712143..3712469 - 327 WP_004936551.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(27-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13163.93 Da        Isoelectric Point: 4.9139

>T108897 WP_025303801.1 NZ_CP031316:c3708408-3708052 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHGRQEGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRRLTE

Download         Length: 357 bp

>T108897 NZ_CP031316:c3708408-3708052 [Serratia marcescens]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAGTTCAATGCTGAAATTGTGCCTCACGGCCGCCAGGAAGGCAGCAAAGT
TGAGGCTGTAGCCAACCGCGTGCTCAATGCTTACCACTACGAGAACGTCACAGACGTATACCGCTTGGCTGCGCTCTATC
TCATCGCCATCAGCCACGGTCACATTTTTCTTGATGGCAACAAACGTACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGACGCAGAACTGGTCGAAATTACGGTTGAAGCAGCTCAAGGCCGCCTCAACGTAGA
ACAAGCCGCTGAACACTTACGCCGGCTAACCGAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT108897 WP_004936539.1 NZ_CP031316:c3708614-3708405 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT108897 NZ_CP031316:c3708614-3708405 [Serratia marcescens]
ATGACTACGATTAGCTACACGGCGGCGAGAAACAATTTGGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCCGACTATGAGGTTTTGGTCAAAGCCAAAGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCGAATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References