Detailed information of TA system TA108887

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1671847..1672372
• Replicon: chromosome
• Accession: NZ_CP031316
• Organism: Serratia marcescens strain N4-5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: Smn45_RS08000
• Protein ID: WP_015377296.1
• Coordinates: 1671847..1672131 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8B4GIN1
• Locus tag: Smn45_RS08005
• Protein ID: WP_004928423.1
• Coordinates: 1672121..1672372 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Smn45_RS07975	1667107..1668240	+	1134	WP_033640832.1	putrescine ABC transporter ATP-binding subunit PotG	-
Smn45_RS07980	1668265..1669227	+	963	WP_016928361.1	putrescine ABC transporter permease PotH	-
Smn45_RS07985	1669224..1670069	+	846	WP_016928360.1	putrescine ABC transporter permease PotI	-
Smn45_RS07990	1670174..1670653	+	480	WP_028127974.1	YbjO family protein	-
Smn45_RS07995	1670723..1671850	+	1128	WP_115435807.1	23S rRNA (uracil(747)-C(5))-methyltransferase RlmC	-
Smn45_RS08000	1671847..1672131	-	285	WP_015377296.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Smn45_RS08005	1672121..1672372	-	252	WP_004928423.1	prevent-host-death protein	Antitoxin
Smn45_RS08010	1672474..1673208	-	735	WP_016928355.1	arginine ABC transporter substrate-binding protein	-
Smn45_RS08015	1673408..1674076	-	669	WP_033637817.1	arginine ABC transporter permease ArtM	-
Smn45_RS08020	1674076..1674792	-	717	WP_028127976.1	arginine ABC transporter permease ArtQ	-
Smn45_RS08025	1674802..1675533	-	732	WP_004928409.1	arginine ABC transporter substrate-binding protein	-
Smn45_RS08030	1675566..1676294	-	729	WP_115436703.1	arginine ABC transporter ATP-binding protein ArtP	-
Smn45_RS08035	1676558..1677100	-	543	WP_028127978.1	lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10803.94 Da
• Isoelectric Point: 10.6941

>T108887 WP_015377296.1 NZ_CP031316:c1672131-1671847 [Serratia marcescens]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLASVLVNPHIPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
RERSAAYTAAKKRL

Nucleotide

• Length: 285 bp

>T108887 NZ_CP031316:c1672131-1671847 [Serratia marcescens]
ATGACTTATAAGCTTGAATTCGAAGAACATGCGCTGAAGGAATTTAAAAAACTGTCCCCGGTGATCCGGGAACAGTTCAA
AAAAAAGCTGGCATCGGTGCTGGTTAATCCCCACATCCCCGCCAACAAACTCGCCGGTTTGCCTGATTGCTACAAAATCA
AACTCAGAGCCTCAGGCTTTCGTTTGGTATATCGCGTCATGGAAACGGAGATCGTGGTTCTGGTCCTGTCTGTGGGCAAA
CGCGAACGTTCAGCGGCTTACACGGCTGCCAAAAAGCGCCTTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9108.39 Da
• Isoelectric Point: 4.5203

>AT108887 WP_004928423.1 NZ_CP031316:c1672372-1672121 [Serratia marcescens]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Nucleotide

• Length: 252 bp

>AT108887 NZ_CP031316:c1672372-1672121 [Serratia marcescens]
ATGACGGTTCAACCCATTCTTGCCGACTCGGCAGTCAGCATCAGCGATTTTAAGAAATCGCCCAACGCCGCCCTTAAAGA
GGCACAAGGGCAACCGGTCGCCGTCCTGACCAACGGTAAGATTTCGGGATATTACGTCTCTCCGGAAACCTGGGAGGCGA
TCGCGGAGTACCTGGAAGATATCGAACTCGCTGAAATCGTTCGTTCACGGATGAACGGCAAACGCATTAAGGTCAATTTG
GATGACTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GIN1