Detailed information of TA system TA108885

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 1193215..1193981
• Replicon: chromosome
• Accession: NZ_CP031316
• Organism: Serratia marcescens strain N4-5

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: Smn45_RS05650
• Protein ID: WP_115435687.1
• Coordinates: 1193613..1193981 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: Smn45_RS05645
• Protein ID: WP_115435686.1
• Coordinates: 1193215..1193553 (+)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Smn45_RS05620	1188565..1189041	+	477	WP_115435682.1	hypothetical protein	-
Smn45_RS05625	1189571..1190731	+	1161	WP_115435683.1	putative lipopolysaccharide heptosyltransferase III	-
Smn45_RS05630	1190784..1192028	+	1245	WP_115435684.1	O-antigen ligase family protein	-
Smn45_RS05635	1192223..1192681	+	459	WP_115435685.1	antirestriction protein	-
Smn45_RS05640	1192707..1193186	+	480	WP_077038928.1	DNA repair protein RadC	-
Smn45_RS05645	1193215..1193553	+	339	WP_115435686.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
Smn45_RS05650	1193613..1193981	+	369	WP_115435687.1	TA system toxin CbtA family protein	Toxin
Smn45_RS05655	1193978..1194307	+	330	WP_077038884.1	hypothetical protein	-
Smn45_RS24450	1194406..1194579	+	174	WP_162807740.1	hypothetical protein	-
Smn45_RS05660	1194779..1195008	-	230	Protein_1064	tyrosine-type recombinase/integrase	-
Smn45_RS05665	1195203..1195514	-	312	WP_115435688.1	hypothetical protein	-
Smn45_RS24585	1195871..1196014	+	144	WP_016928795.1	hypothetical protein	-
Smn45_RS05670	1196140..1197672	+	1533	WP_115435689.1	glycosyltransferase family 39 protein	-
Smn45_RS05675	1197997..1198548	+	552	WP_004940045.1	flavodoxin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1148061..1194307	46246

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (9-107)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13352.30 Da
• Isoelectric Point: 8.5227

>T108885 WP_115435687.1 NZ_CP031316:1193613-1193981 [Serratia marcescens]
MRTVHAPPSRAAQTCPSPITVWQSLLTYLLAQHYGLTLNDTAFSDDAVIQSHIDDGISLADTLNAMVEKFDLVRIDRRGF
SGLAQSPLVTAIDILRARRACGLMTRAGYREVTRAIQGGKQP

Nucleotide

• Length: 369 bp

>T108885 NZ_CP031316:1193613-1193981 [Serratia marcescens]
ATGCGAACAGTACACGCACCACCCTCACGGGCGGCCCAAACATGCCCGTCCCCCATAACTGTCTGGCAATCCTTGCTCAC
CTACCTGCTGGCGCAGCACTACGGCCTGACGCTCAACGACACTGCATTCAGCGACGATGCCGTAATACAGTCACATATCG
ATGACGGTATCTCCCTCGCGGATACGCTGAATGCCATGGTGGAAAAGTTTGATCTGGTACGCATTGACCGCCGGGGCTTC
AGCGGTCTGGCGCAATCGCCCCTTGTGACCGCCATCGACATCTTGCGCGCCCGCAGGGCCTGCGGCCTGATGACGCGAGC
CGGTTACCGGGAGGTCACACGTGCCATTCAGGGAGGCAAGCAACCATGA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12774.54 Da
• Isoelectric Point: 6.6295

>AT108885 WP_115435686.1 NZ_CP031316:1193215-1193553 [Serratia marcescens]
MTSTKNVPSWGLKRNVTPQFGARLIQEGERLHFLADRADISGIFSDAQRHDLEKAFPQFINHLELMLLSGELNPRYQHCV
TLYCHGLTCEADSLGSYGYVYLSIYPTPEMPR

Nucleotide

• Length: 339 bp

>AT108885 NZ_CP031316:1193215-1193553 [Serratia marcescens]
ATGACATCGACCAAGAACGTCCCATCATGGGGACTGAAACGCAACGTCACGCCGCAGTTTGGCGCCCGTCTGATACAAGA
GGGGGAACGACTGCATTTTCTGGCCGACCGCGCTGACATCAGCGGGATTTTCAGCGACGCACAGCGCCATGATTTGGAGA
AGGCTTTTCCGCAGTTCATCAACCACCTGGAATTGATGCTGCTCTCCGGTGAGCTCAATCCGCGTTATCAGCACTGTGTC
ACACTGTATTGCCATGGCCTGACCTGCGAAGCCGACAGCCTGGGCTCATACGGCTACGTTTATCTCTCGATTTATCCGAC
ACCTGAAATGCCCAGGTAA